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1. (WO2018183211) SEMI-QUANTITATIVE LATERAL-FLOW IMMUNOASSAY FOR THE DETECTION OF CSF LEAKS

Pub. No.:    WO/2018/183211    International Application No.:    PCT/US2018/024392
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Tue Mar 27 01:59:59 CEST 2018
IPC: G01N 33/543
C12M 1/34
G01N 33/74
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: KAMEI, Daniel T.
ST JOHN, Maie A.
TAYLOR, Zachary D.
BRADBURY, Daniel W.
KITA, Ashley E.
Title: SEMI-QUANTITATIVE LATERAL-FLOW IMMUNOASSAY FOR THE DETECTION OF CSF LEAKS
Abstract:
Devices and methods are provided tor the detection of CSF in a biological sample. In certain embodiments the device is a lateral flow device comprising: a porous substrate; a sample addition zone disposed on or in said porous substrate; a detection zone disposed on or in said porous substrate where said detection zone comprises at least a first test line (Tl) and a second test line (T2) each test line comprising binding moieties that bind a complex formed between beta-trace protein (betaTP) and an indicator attached t a betaTP binding molecule; wherein said porous substrate defines a flow path through which a sample applied to the sample addition zone flows under capillary action away from said sample addition zone into said detection zone.