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1. (WO2018182527) METHOD FOR TREATING INFLAMMATORY COMPLICATIONS IN EYE DISEASES

Pub. No.:    WO/2018/182527    International Application No.:    PCT/SG2018/050156
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 30 01:59:59 CEST 2018
IPC: A61K 31/444
C07K 16/28
A61K 39/395
A61P 27/02
Applicants: NATIONAL UNIVERSITY OF SINGAPORE
Inventors: SILVER, David Lawrence
WONG, Bernice Huimin
Title: METHOD FOR TREATING INFLAMMATORY COMPLICATIONS IN EYE DISEASES
Abstract:
The invention relates to methods of using inhibitors of CSF-1 R for reducing microglial activation in the eye as well as treating an inflammation associated with an eye disease, such as age-related macular degeneration (AMD), retinitis pigmentosa and diabetic retinopathy. The methods can further comprise the administration of anti-VEGF antibody. In preferred embodiments, the CSF-1 R inhibitor is Pexidartinib (PLX3397).