WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Options
Query Language
Stem
Sort by:
List Length
Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018182523) AGENT
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/182523 International Application No.: PCT/SG2018/050152
Publication Date: 04.10.2018 International Filing Date: 28.03.2018
IPC:
C07K 16/20 (2006.01) ,C07K 16/28 (2006.01) ,A61K 39/395 (2006.01) ,A61P 33/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
20
from protozoa
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
02
Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
06
Antimalarials
Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH[SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower Singapore 138632, SG
Inventors: MALLERET, Benoit; SG
RÉNIA, Laurent; SG
RUSSELL, Bruce; NZ
Agent: AMICA LAW LLC; 30 Raffles Place, #14-01 Chevron House Singapore 048622, SG
Priority Data:
10201702519X28.03.2017SG
Title (EN) AGENT
(FR) AGENT
Abstract:
(EN) The present invention relates to a vaccine for therapeutic or prophylactic treatment of a pathological condition. In particular, the present invention relates to a vaccine for therapeutic or prophylactic treatment of malaria. In an aspect of the present invention, there is provided an agent having a specificity for a PvRBP, especially PvRBP2a expressed on the surface of a merozoite of Plasmodium vivax, or a human CD98, wherein the agent blocks or reduces binding of the PvRBP2a with the human CD98. This invention further comprises a bispecific antibody that binds to human CD98 and CD147 that can be used to block or reduce the binding of Plasmodium vivax and Plasmodium falciparum to human CD98 and CD147.
(FR) La présente invention concerne un vaccin destiné au traitement thérapeutique ou prophylactique d'un état pathologique. En particulier, la présente invention concerne un vaccin destiné au traitement thérapeutique ou prophylactique du paludisme. Selon un aspect de la présente invention, l'invention concerne un agent présentant une spécificité pour un PvRBP, en particulier le PvRBP2a exprimé sur la surface d'un mérozoïte de Plasmodium vivax, ou un CD98 humain, l'agent bloquant ou réduisant la liaison du PvRBP2a au CD98 humain. La présente invention comprend en outre un anticorps bispécifique qui se lie aux CD98 et CD147 humains, qui peut être utilisé pour bloquer ou réduire la liaison de Plasmodium vivax et de Plasmodium falciparum aux CD98 et CD147 humains.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)