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1. (WO2018182518) A METHOD OF PREPARING SILICA NANOCAPSULES AND SILICA NANOCAPSULES

Pub. No.:    WO/2018/182518    International Application No.:    PCT/SG2018/050147
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Thu Mar 29 01:59:59 CEST 2018
IPC: B01J 13/02
A61K 9/51
A61K 47/02
C01B 33/14
B82Y 5/00
Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventors: PARK, Eun Ju
M. VAN HERK, Alexander
THONIYOT, Praveen
Title: A METHOD OF PREPARING SILICA NANOCAPSULES AND SILICA NANOCAPSULES
Abstract:
There is provided a method of preparing silica nanocapsules, the method comprising mixing a surfactant with water at a temperature that is above the gel-to-liquid transition temperature of the surfactant to form a mixture, passing the mixture one or more times through at least one pore to obtain a dispersion of vesicles, and adding a silica precursor to the dispersion of vesicles to form silica nanocapsules. Also provided is a silica nanocapsule formed from a vesicle template, and a method of delivering one or more types of molecules to a subject. In a specific embodiment, hollow silica nanocapsules having substantially lens-shaped are synthesized by employing dimethyldioctadecylammonium bromide (DODAB) or dioctadecyldimethyl ammonium chloride (DODAC) as the vesicle template and tetraethyl orthosilicate (TEOS) as the silica precursor.