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1. (WO2018182422) ERBB-2 AND ERBB3 BINDING BISPECIFIC ANTIBODIES FOR USE IN THE TREATMENT F CELLS THAT HAVE AN NRG1 FUSION GENE

Pub. No.:    WO/2018/182422    International Application No.:    PCT/NL2018/050206
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Apr 04 01:59:59 CEST 2018
IPC: A61K 39/395
C07K 16/28
C07K 16/30
C07K 16/32
Applicants: MERUS N.V.
Inventors: THROSEY, Mark
GEUIJEN, Cecilia Ana Wilhelmina
MAUSSANG-DETAILLE, David Andre Baptiste
LOGTENBERG, Ton
Title: ERBB-2 AND ERBB3 BINDING BISPECIFIC ANTIBODIES FOR USE IN THE TREATMENT F CELLS THAT HAVE AN NRG1 FUSION GENE
Abstract:
The invention relates to the field of antibodies. In particular it relates to the field of therapeutic (human) antibodies for the treatment of ErbB-2/ErbB-3 positive cells. More in particular it relates to treating of cells comprising an NRG1 fusion gene comprising at least a portion of the NRG1-gene fused to a sequence from a different chromosomal location.