Search International and National Patent Collections

1. (WO2018182421) ERBB-2 TARGETING AGENT AND A BISPECIFIC ANTIBODY WITH ANTIGEN-BINDING SITES THAT BIND AN EPITOPE ON AN EXTRACELLULAR PART OF ERB-2 AND ERBB-3, FOR TREATMENT OF AN INDIVIDUAL WITH AN ERBB-2, ERBB-2/ERBB-3 POSITIVE TUMOUR

Pub. No.:    WO/2018/182421    International Application No.:    PCT/NL2018/050205
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Apr 04 01:59:59 CEST 2018
IPC: A61K 39/395
C07K 16/28
C07K 16/32
C07K 16/46
C07K 16/30
Applicants: MERUS N.V.
Inventors: THROSBY, Mark
GEUIJEN, Cecilia Anna Wilhelmina
MAUSSANG-DETAILLE, David Andre Baptiste
LOGTENBERG, Ton
Title: ERBB-2 TARGETING AGENT AND A BISPECIFIC ANTIBODY WITH ANTIGEN-BINDING SITES THAT BIND AN EPITOPE ON AN EXTRACELLULAR PART OF ERB-2 AND ERBB-3, FOR TREATMENT OF AN INDIVIDUAL WITH AN ERBB-2, ERBB-2/ERBB-3 POSITIVE TUMOUR
Abstract:
The invention relates among others to antibodies comprising a first antigen- binding site that binds ErbB-2 and a second antigen-binding site that binds ErbB- 3. The antibodies can typically reduce a ligand-induced receptor function of ErbB-3 on a ErbB-2 and ErbB-3 positive cell. Also described are method for the treatment and use of the antibodies in imaging and in the treatment of subjects having an ErbB-2, ErbB-3 or ErbB-2/3 positive tumor.