Search International and National Patent Collections

1. (WO2018182372) DIAGNOSTIC IMAGING HEPATIC TISSUE-SPECIFIC CONTRAST MEDIUM COMPRISING MANGANESE SILICATE NANOPARTICLE

Pub. No.:    WO/2018/182372    International Application No.:    PCT/KR2018/003810
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Sat Mar 31 01:59:59 CEST 2018
IPC: A61K 49/18
Applicants: POSTECH ACADEMY-INDUSTRY FOUNDATION
포항공과대학교 산학협력단
RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
성균관대학교 산학협력단
Inventors: LEE, Won Jae
이원재
LEE, Jung Hee
이정희
JANG, Moon Sun
장문선
LEE, In Su
이인수
KIM, Jin Goo
김진구
Title: DIAGNOSTIC IMAGING HEPATIC TISSUE-SPECIFIC CONTRAST MEDIUM COMPRISING MANGANESE SILICATE NANOPARTICLE
Abstract:
The present invention relates to a diagnostic imaging manganese silicate hepatic tumor-specific MRI contrast medium which releases manganese ions (Mn2+) in an acidic condition and a method for characterizing a hepatic tissue, using the same. Exhibiting different patterns of T1-weighted imaging including vascularity, cell density, mitochondrial activity, hepatocellular affinity, etc., according to tissue specificity of normal hepatic tissues and diseased liver tissues (particularly hepatic tumor), within relatively short period of time, the present invention allows disease-specific characteristics of hepatic tumor to be detected at an appropriate time through the analysis of such T1-weighted imaging. Particularly, the present invention is expected to be very effectively used in discerning and diagnosing kinds of hepatic tumor or in determining therapeutic effects and further to be helpful in diagnosing diseases generated in organs other than the liver according to tissue specificity.