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1. (WO2018182341) PYRROLOBENZODIAZEPINE DIMER PRECURSOR AND LIGAND-LINKER CONJUGATE COMPOUND THEREOF

Pub. No.:    WO/2018/182341    International Application No.:    PCT/KR2018/003744
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 30 01:59:59 CEST 2018
IPC: C07D 487/04
A61K 31/5517
Applicants: LEGOCHEM BIOSCIENCES, INC.
주식회사 레고켐 바이오사이언스
Inventors: SONG, Ho Young
송호영
KIM, Sung Min
김성민
KIM, Hyoung Rae
김형래
PARK, Kyung Eun
박경은
CHUNG, Chul-Woong
정철웅
PARK, Yun-Hee
박윤희
CHOI, Hyo Jung
최효정
LEE, Su In
이수인
BAEK, Juyuel
백주열
LEE, Hyeun Joung
이현정
LEE, Ju Young
이주영
OH, Jihye
오지혜
CHAE, Jeiwook
채제욱
OH, Yeong Soo
오영수
KIM, Yong Zu
김용주
Title: PYRROLOBENZODIAZEPINE DIMER PRECURSOR AND LIGAND-LINKER CONJUGATE COMPOUND THEREOF
Abstract:
The present invention relates to a pyrrolobenzodiazepine precursor and a ligand-linker conjugate compound thereof, a composition containing the same, and, in particular, a therapeutic use thereof as an anti-cancer agent. The present invention is industrially useful in that it is possible to target proliferative diseases such as cancer, perform a specific treatment, maximize medicinal effects, and minimize the occurrence of side effects, since the compound itself is very stable, has excellent stability in plasma, and has advantages in terms of toxicity manifestation.