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1. (WO2018182284) ANTIBODY BINDING SPECIFICALLY TO N-TERMINAL REGION OF LYSYL-TRNA SYNTHETASE EXPOSED ON CELL MEMBRANE
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Pub. No.: WO/2018/182284 International Application No.: PCT/KR2018/003594
Publication Date: 04.10.2018 International Filing Date: 27.03.2018
IPC:
A61K 39/395 (2006.01) ,C07K 16/40 (2006.01) ,G01N 33/574 (2006.01) ,A61K 39/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
Applicants:
재단법인 의약바이오컨버젼스연구단 MEDICINAL BIOCONVERGENCE RESEARCH CENTER [KR/KR]; 경기도 수원시 영통구 광교로 145 차세대융합기술연구원내 B동 8층 (이의동) (Iui-dong) 8th Fl., B-dong Advanced Institutes of Convergence Technology, 145 Gwanggyo-ro, Yeongtong-gu, Suwon-si Gyeonggi-do 16229, KR
Inventors:
김성훈 KIM, Sunghoon; KR
심현보 SHIM, Hyun Bo; KR
권남훈 KWON, Nam Hoon; KR
한대영 HAN, Dae Young; KR
Agent:
이희숙 LEE, Hee Sook; 서울특별시 강남구 테헤란로 33길 11, 9층 (역삼동, JS빌딩) (JS Building, Yeoksam-dong) 9th Fl. 11, Teheran-ro 33 gil, Gangnam-gu Seoul 06141, KR
Priority Data:
10-2017-003877527.03.2017KR
10-2017-011889015.09.2017KR
10-2017-011891715.09.2017KR
Title (EN) ANTIBODY BINDING SPECIFICALLY TO N-TERMINAL REGION OF LYSYL-TRNA SYNTHETASE EXPOSED ON CELL MEMBRANE
(FR) ANTICORPS SE LIANT SPÉCIFIQUEMENT À LA RÉGION N-TERMINALE DE LA LYSYL-ARNT SYNTHÉTASE EXPOSÉE SUR UNE MEMBRANE CELLULAIRE
(KO) 세포 외막에 노출되는 라이실-tRNA 합성효소 N-말단 영역에 특이적으로 결합하는 항체
Abstract:
(EN) The present invention relates to an antibody binding specifically to an N-terminal region of lysyl-tRNA synthetase which is exposed on the cell membrane and a use thereof and, more particularly, to an antibody having a certain complementary determining region (CDR) stipulated in the specification and binding specifically to an epitope including the sequence of SEQ ID NO: 97 in a lysyl-tRNA synthetase (KRS) N-terminal, or a fragment thereof, a use of the antibody or a fragment thereof in metastasis suppression and cancer diagnosis, and a pharmaceutical composition for prevention or treatment of an immune cell migration-related disease. Far superior in specific binding affinity to a KRS N-terminal region exposed on the cell membrane, the antibody or fragments thereof according to the present invention are effective for cancer diagnosis, have anti-cancer and metastasis inhibition effects, and can be very useful for preventing or treating an immune cell migration-related disease.
(FR) La présente invention concerne un anticorps se liant spécifiquement à une région N-terminale de la lysyl-ARNt synthétase qui est exposée sur la membrane cellulaire et son utilisation et, plus particulièrement, un anticorps ayant une certaine région de détermination complémentaire (CDR) stipulée dans la description et se liant spécifiquement à un épitope comprenant la séquence de SEQ ID NO : 97 dans dans une région N-terminale de la lysyl-ARNt synthétase (KRS) ou son fragment, une utilisation de l'anticorps ou de son fragment dans la suppression des métastases et le diagnostic du cancer et une composition pharmaceutique pour la prévention ou le traitement d'une maladie liée à la migration des cellules immunitaires. Une affinité de liaison spécifique bien supérieure à une région N-terminale KRS exposée sur la membrane cellulaire, l'anticorps ou ses fragments selon la présente invention sont efficaces pour le diagnostic du cancer, ont des effets anticancéreux et d'inhibition de métastases et peuvent être très utiles pour prévenir ou traiter une maladie liée à la migration des cellules immunitaires.
(KO) 본 발명은 세포 외막에 노출되는 라이실-tRNA 합성효소 N-말단 영역에 특이적으로 결합하는 항체와 이의 이용에 관한 것으로, 보다 상세하게는 본 명세서에서 기재하는 특정 CDR (상보성 결정부위) 서열을 가지며 라이실-tRNA 합성효소 (KRS, Lysyl-tRNA synthetase) N-말단 중에서 서열번호 97의 서열을 포함하는 에피토프 (epitope)에 특이적으로 결합하는 항체 또는 그 단편과, 상기 항체 또는 단편의 암 전이 억제 용도, 암 진단 용도 및 면역세포 이동 관련 질환의 예방 또는 치료용 약 학적 조성물에 대한 것이다. 본 발명에 따른 항체 또는 그 단편들은 세포 외막에 노출되는 KRS N-말단 영역에 특이적 결합능력이 매우 우수하기 때문에, 암 진단에 효과가 있고, 항암 및 암 전이 억제 효과가 있으며, 면역세포 이동과 관련한 질환을 예방 및 치료하는 데에 매우 유용하게 이용될 수 있다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)