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1. (WO2018181866) NOROVIRUS ANTIBODY
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/181866 International Application No.: PCT/JP2018/013543
Publication Date: 04.10.2018 International Filing Date: 30.03.2018
IPC:
C12N 15/13 (2006.01) ,A01H 5/10 (2018.01) ,A01H 6/46 (2018.01) ,A23L 7/10 (2016.01) ,A61K 39/395 (2006.01) ,A61P 31/14 (2006.01) ,C07K 16/10 (2006.01) ,C12N 1/15 (2006.01) ,C12N 1/19 (2006.01) ,C12N 1/21 (2006.01) ,C12N 5/10 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
12
Genes encoding animal proteins
13
Immunoglobulins
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
H
NEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
5
Flowering plants, i.e. angiosperms
10
Seeds
[IPC code unknown for A01H 6/46][IPC code unknown for A23L 7/10]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08
against material from viruses
10
from RNA viruses
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
15
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
14
Fungi; Culture media therefor
16
Yeasts; Culture media therefor
19
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
21
modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
Applicants: THE UNIVERSITY OF TOKYO[JP/JP]; 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654, JP
Inventors: YUKI Yoshikazu; JP
KIYONO Hiroshi; JP
KUROKAWA Shiho; JP
Agent: OKUHARA Koji; JP
SEKIMOTO Sumito; JP
Priority Data:
2017-07075731.03.2017JP
Title (EN) NOROVIRUS ANTIBODY
(FR) ANTICORPS DE NOROVIRUS
(JA) ノロウイルス抗体
Abstract:
(EN) The purpose of the present invention is to provide an antibody capable of inhibiting the infection of a cell with a norovirus. A nano antibody which contains a polypeptide as mentioned in (a), (b) or (c) and can inhibit the infection of an intestinal cell with HuNoV GII.3 and/or HuNoV GII.4: (a) a polypeptide comprising an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9 or SEQ ID NO: 13; (b) a polypeptide comprising an amino acid sequence produced by substituting, deleting, inserting and/or adding one or several amino acid residues in an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9 or SEQ ID NO: 13; and (c) a polypeptide comprising an amino acid sequence having a 80% or higher sequence identity to an amino acid sequence represented by SEQ ID NO: 1, SEQ ID NO: 5, SEQ ID NO: 9 or SEQ ID NO: 13.
(FR) L'objet de la présente invention est de fournir un anticorps capable d’inhiber l’infection d’une cellule par un norovirus. À cet effet, l'invention concerne un nanoanticorps qui contient un polypeptide tel que mentionné en (a), (b) ou (c) et peut inhiber l’infection d’une cellule intestinale avec HuNoV GII.3 et/ou HuNoV GII.4 : (a) un polypeptide comprenant une séquence d’acides aminés représentée par SEQ ID no : 1, SEQ ID no : 5, SEQ ID no : 9 ou SEQ ID no : 13 ; (b) un polypeptide comprenant une séquence d’acides aminés produite par substitution, délétion, insertion et/ou addition d’un ou plusieurs résidus d’acides aminés dans une séquence d’acides aminés représentée par SEQ ID no : 1, SEQ ID no : 5, SEQ ID no : 9 ou SEQ ID no : 13 ; et (c) un polypeptide comprenant une séquence d’acides aminés ayant 80 % ou plus d’identité de séquence vis-à-vis d’une séquence d’acides aminés représentée par SEQ ID no : 1, SEQ ID no : 5, SEQ ID no : 9 ou SEQ ID no : 13.
(JA) 本発明は、ノロウイルスの細胞への感染を阻害する抗体の提供を目的とするもので、下記(a)、(b)または(c)に記載のポリペプチドを含むナノ抗体であって、HuNoV GII.3および/またはHuNoV GII.4の腸管細胞への感染を阻害するナノ抗体である。 (a)配列番号1、配列番号5、配列番号9もしくは配列番号13で表されるアミノ酸配列からなるポリペプチド、 (b)配列番号1、配列番号5、配列番号9もしくは配列番号13で表されるアミノ酸配列において、1もしくは数個のアミノ酸が置換、欠失、挿入および/または付加されたアミノ酸配列からなるポリペプチド、および、 (c)配列番号1、配列番号5、配列番号9もしくは配列番号13で表されるアミノ酸配列と80%以上の配列同一性を有するアミノ酸配列からなるポリペプチド
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)