Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018181820) HETEROCYCLIC COMPOUND
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/181820 International Application No.: PCT/JP2018/013469
Publication Date: 04.10.2018 International Filing Date: 29.03.2018
IPC:
C07D 487/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 1/16 (2006.01) ,A61P 9/12 (2006.01) ,A61P 11/00 (2006.01) ,A61P 13/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
12
of the kidneys
Applicants:
武田薬品工業株式会社 TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 大阪府大阪市中央区道修町四丁目1番1号 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410045, JP
Inventors:
松永 伸之 MATSUNAGA, Nobuyuki; JP
藤本 卓也 FUJIMOTO, Takuya; JP
藤本 潤 FUJIMOTO, Jun; JP
森本 幸恵 MORIMOTO, Sachie; JP
筧 広行 KAKEI, Hiroyuki; JP
松尾 孝徳 MATSUO, Takanori; JP
村木 暢 MURAKI, Yo; JP
内藤 貴子 NAITO, Takako; JP
加藤 珠蘭 KATO, Juran; JP
長袋 洋 NAGABUKURO, Hiroshi; JP
仁尾 泰徳 NIO, Yasunori; JP
大川原 賦 OOKAWARA, Mitsugi; JP
土屋 俊太郎 TSUCHIYA, Shuntaro; JP
Agent:
青木 篤 AOKI, Atsushi; JP
三橋 真二 MITSUHASHI, Shinji; JP
渡辺 陽一 WATANABE, Yoichi; JP
中島 勝 NAKAJIMA, Masaru; JP
武居 良太郎 TAKEI, Ryotaro; JP
Priority Data:
2017-07239631.03.2017JP
Title (EN) HETEROCYCLIC COMPOUND
(FR) COMPOSÉ HÉTÉROCYCLIQUE
(JA) 複素環化合物
Abstract:
(EN) The present invention relates to a compound that can be effective for prevention and/or treatment of pulmonary hypertension, pulmonary fibrosis, fibrosis in the liver, kidney, skin, or heart, non-alcoholic steatohepatitis, diabetic nephropathy, and the like. A compound, or a salt thereof, selected from: 4-[2-(cyclopropylmethoxy)-5-(difluoromethyl)phenyl]-N-{4-[(N,N-dimethylglycyl)amino]cyclohexyl}-6-methyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; 4-(5-(difluoromethyl)-2-{[1-(difluoromethyl)cyclopropyl]methoxy}phenyl)-6-methyl-N-[4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide; and 4-{2-[(3-fluoropyridine-2-yl)methoxy]-5-(trifluoromethyl)phenyl}-6-methyl-N-[4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide.
(FR) La présente invention concerne un composé qui peut être efficace pour la prévention et/ou le traitement de l'hypertension pulmonaire, de la fibrose pulmonaire, de la fibrose hépatique, rénale, cutanée ou cardiaque, de la stéatohépatite non alcoolique, de la néphropathie diabétique et autres. L'invention concerne un composé, ou un sel correspondant, choisi parmi : le 4-[2-(cyclopropylméthoxy)-5-(difluorométhyl)phényl]-N-{4-[(N,N-diméthylglycyl)amino]cyclohexyl}-6-méthyl-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide ; le 4-(5-(difluorométhyl)-2-{[1-(difluorométhyl)cyclopropyl]méthoxy}phényl)-6-méthyl-N-[4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide ; et le 4-{2-[(3-fluoropyridine-2-yl)méthoxy]-5-(trifluorométhyl)phényl}-6-méthyl-N-[4-(propionylamino)cyclohexyl]-5H-pyrrolo[3,2-d]pyrimidine-7-carboxamide.
(JA) 本発明は、肺高血圧症、肺線維症、肝臓、腎臓、皮膚または心臓における線維症、非アルコール性脂肪肝炎、糖尿病性腎症等の予防および/または治療に有用であり得る化合物に関する。 4-[2-(シクロプロピルメトキシ)-5-(ジフルオロメチル)フェニル]-N-{4-[(N,N-ジメチルグリシル)アミノ]シクロヘキシル}-6-メチル-5H-ピロロ[3,2-d]ピリミジン-7-カルボキサミド; 4-(5-(ジフルオロメチル)-2-{[1-(ジフルオロメチル)シクロプロピル]メトキシ}フェニル)-6-メチル-N-[4-(プロピオニルアミノ)シクロヘキシル]-5H-ピロロ[3,2-d]ピリミジン-7-カルボキサミド;および 4-{2-[(3-フルオロピリジン-2-イル)メトキシ]-5-(トリフルオロメチル)フェニル}-6-メチル-N-[4-(プロピオニルアミノ)シクロヘキシル]-5H-ピロロ[3,2-d]ピリミジン-7-カルボキサミド から選ばれる化合物またはその塩。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)