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1. (WO2018181428) COMPLEX OF NUCLEIC ACID MEDICINE AND MULTIBRANCHED LIPID
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/181428 International Application No.: PCT/JP2018/012649
Publication Date: 04.10.2018 International Filing Date: 28.03.2018
IPC:
A61K 31/7088 (2006.01) ,A61K 47/50 (2017.01) ,C12N 15/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
[IPC code unknown for A61K 47/50]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
Applicants: SHIONOGI & CO., LTD.[JP/JP]; 1-8, Doshomachi 3-chome, Chuo-ku, Osaka-shi, Osaka 5410045, JP
Inventors: KUGIMIYA Akira; JP
SEKIGUCHI Mitsuaki; JP
KURODA Norikazu; JP
NAKAMURA Jun; JP
TANINO Tetsuya; JP
MITSUOKA Yasunori; JP
KASUYA Takeshi; JP
KATO Yasuharu; JP
Agent: YAMAUCHI Hideaki; JP
SUGITA Ken-ichi; JP
Priority Data:
2017-06433629.03.2017JP
Title (EN) COMPLEX OF NUCLEIC ACID MEDICINE AND MULTIBRANCHED LIPID
(FR) COMPLEXE DE MÉDICAMENT D'ACIDE NUCLÉIQUE ET DE LIPIDE MULTIRAMIFIÉ
(JA) 核酸医薬及び多分岐脂質の複合体
Abstract:
(EN) The purpose of the present invention is to provide a novel complex that improves the effect of nucleic acid medicines. Provided is a complex in which a multibranched lipid is bonded via a linker to a chain of an oligonucleotide such as a nucleic acid medicine capable of suppressing the expression of a target gene.
(FR) Le but de la présente invention est de fournir un nouveau complexe qui améliore l'effet de médicaments à base d'acide nucléique. L'invention concerne un complexe dans lequel un lipide multiramifié est lié par l'intermédiaire d'un lieur à une chaîne d'un oligonucléotide tel qu'un médicament d'acide nucléique capable de supprimer l'expression d'un gène cible.
(JA) 本発明の目的は、核酸医薬の効果を向上させる新規の複合体を提供することにある。 標的遺伝子の発現抑制活性を有する核酸医薬を含むオリゴヌクレオチドの鎖に多分岐脂質がリンカーを介して結合している複合体。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)