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1. (WO2018181298) STABLE PRODUCTION AND USE OF HIGHLY VIRULENT ENTEROVIRUS 71

Pub. No.:    WO/2018/181298    International Application No.:    PCT/JP2018/012410
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Mar 28 01:59:59 CEST 2018
IPC: C12N 5/10
C12N 7/00
C12Q 1/70
G01N 33/15
G01N 33/50
C12N 15/09
Applicants: TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE
公益財団法人東京都医学総合研究所
Inventors: KOIKE, Satoshi
小池 智
KOBAYASHI, Kyousuke
小林 郷介
SUDAKA, Yui
巣鷹 佑衣
IMURA, Ayumi
猪村 亜弓
Title: STABLE PRODUCTION AND USE OF HIGHLY VIRULENT ENTEROVIRUS 71
Abstract:
Provided is a host cell for use in the stable proliferation of a highly virulent pathogenic virus for hand, foot and mouth disease, which does not express heparan sulfate and overexpresses primate scavenger receptor class B member 2 (SCARB2). Also provided is a method for screening for an anti-hand, foot and mouth disease pathogenic virus vaccine or an anti-hand, foot and mouth disease pathogenic virus drug using a stably-proliferated highly-virulent pathogenic virus for hand, foot and mouth disease.