Search International and National Patent Collections

1. (WO2018181294) PHARMACEUTICAL PREPARATION

Pub. No.:    WO/2018/181294    International Application No.:    PCT/JP2018/012403
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Mar 28 01:59:59 CEST 2018
IPC: A61K 31/472
A61K 9/08
A61K 31/4725
A61K 47/02
A61P 27/02
A61P 27/06
Applicants: KOWA COMPANY, LTD.
興和株式会社
Inventors: YAMAKITA, Yoshihiro
山北 佳央
Title: PHARMACEUTICAL PREPARATION
Abstract:
The purpose of the present invention is to establish a technique for stably preparing an isoquinoline-6-amino derivative in the form of a pharmaceutical preparation, e.g., an ophthalmic preparation. A pharmaceutical preparation prepared by enclosing a water-based composition in a container made from a polyolefin resin, wherein the water-based composition contains the following components (A) and (B): (A) a compound represented by general formula (1) (wherein R1 and R2 independently represent a hydrogen atom or a C1-C4 alkyl group, R3 represents a hydrogen atom or a hydroxy group, and A represents -CH(R4)- or -CH2-CH(R4)- (wherein R4 represents a C6-C10 aryl group which may have a substituent or a 5- to 10-membered heteroaryl group which may have a substituent); wherein a tautomer of the compound is also included within the scope of formula (1)), a salt of the compound, or a solvate of the compound or the salt; and (B) at least one component selected from the group consisting of an acid, a quaternary ammonium-type surfactant, a polyhydric alcohol and a prostaglandin compound.