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1. (WO2018180943) METHOD FOR PRODUCING HALOGEN-CONTAINING PYRAZOL CARBOXYLIC ACID AND INTERMEDIATE THEREOF
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Pub. No.: WO/2018/180943 International Application No.: PCT/JP2018/011582
Publication Date: 04.10.2018 International Filing Date: 23.03.2018
IPC:
C07D 231/14 (2006.01) ,A61K 31/415 (2006.01) ,A61P 31/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02
not condensed with other rings
10
having two or three double bonds between ring members or between ring members and non-ring members
14
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
Applicants: AGC INC.[JP/JP]; 5-1, Marunouchi 1-chome, Chiyoda-ku, Tokyo 1008405, JP
Inventors: ISHIBASHI, Yuichiro; JP
Agent: TAKASHIMA, Hajime; JP
KAMADA, Mitsunori; JP
Priority Data:
2017-06168827.03.2017JP
Title (EN) METHOD FOR PRODUCING HALOGEN-CONTAINING PYRAZOL CARBOXYLIC ACID AND INTERMEDIATE THEREOF
(FR) PROCÉDÉ DE PRODUCTION D'ACIDE CARBOXYLIQUE DE PYRAZOLE CONTENANT UN HALOGÈNE ET INTERMÉDIAIRE ASSOCIÉ
(JA) ハロゲン含有ピラゾールカルボン酸及びその中間体の製造方法
Abstract:
(EN) The present invention provides an industrially excellent production method which can more efficiently and conveniently produce a halogen-containing pyrazol carboxylic acid and an intermediate thereof which are useful as a pharmaceutical and agrochemical intermediate. The present invention pertains to a method for producing a compound represented by formula (b), wherein the compound represented by formula (b) is obtained by reacting a compound represented by formula (a) with a halogenating agent selected from the group consisting of a compound represented by X2 (formula (1)), a compound represented by SOX2 (formula (2)), and a compound represented by SO2X2 (formula (3)). Formula (1) X2; formula (2) SOX2; and formula (3) SO2X2 (each symbol in the formulae is as described in the specification).
(FR) La présente invention concerne un procédé de production excellent sur le plan industriel qui peut produire de manière plus efficace et convenable un acide carboxylique de pyrazole contenant un halogène et un intermédiaire de celui-ci qui sont utiles en tant qu'intermédiaires pharmaceutiques et agrochimiques. La présente invention concerne un procédé de production d'un composé représenté par la formule (b), le composé représenté par la formule (b) étant obtenu par réaction d'un composé représenté par la formule (a) avec un agent d'halogénation choisi dans le groupe constitué par un composé représenté par X2 (formule (1)), un composé représenté par SOX2 (formule (2)), et un composé représenté par SO2X2 (formule (3)). Formule (1) X2 ; formule (2) SOX2 ; et formule (3) SO2X2 (chaque symbole dans les formules est tel que décrit dans la description).
(JA) 本発明は、医農薬中間体として有用なハロゲン含有ピラゾールカルボン酸及びその中間体をより簡便に効率よく製造でき、工業的に優れる製造方法を提供する。 本発明は、式(a)で表される化合物と、X(式(1))で表される化合物、SOX(式(2))で表される化合物、及び、SO(式(3))で表される化合物からなる群から選択されるハロゲン化剤とを反応させて、式(b)で表される化合物を得る、式(b)で表される化合物の製造方法に関する。 式(1) X 式(2) SOX 式(3) SO (式中の各記号は明細書に記載の通りである。)
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)