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1. (WO2018180914) HYDROPHILIC POLYMER DERIVATIVE HAVING SELF-IMMOLATIVE ACETAL LINKER AND COMPOSITE USING SAME

Pub. No.:    WO/2018/180914    International Application No.:    PCT/JP2018/011485
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 23 00:59:59 CET 2018
IPC: C08G 65/329
A61K 47/60
Applicants: NOF CORPORATION
日油株式会社
Inventors: TSUBUSAKI Takuma
粒崎 拓真
TAMAGAWA Shinya
玉川 晋也
Title: HYDROPHILIC POLYMER DERIVATIVE HAVING SELF-IMMOLATIVE ACETAL LINKER AND COMPOSITE USING SAME
Abstract:
Provided is a hydrophilic polymer derivative having a novel linker technology, wherein a hydrophilic polymer prodrug such as an amino group-containing drug can be formed to overcome limitations of conventional hydrophilic polymer prodrugs. The hydrophilic polymer derivative comprises a hydrophilic polymer part and an acetal part, and has a structure represented by formula (1) or formula (2).