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1. (WO2018180005) ANTISENSE NUCLEIC ACID FOR INHIBITING BIOSYNTHESIS OF CHONDROITIN SULFATE

Pub. No.:    WO/2018/180005    International Application No.:    PCT/JP2018/005909
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Feb 21 00:59:59 CET 2018
IPC: C12N 15/113
A61K 31/7115
A61K 31/712
A61K 31/7125
A61K 48/00
A61P 25/00
C12N 15/09
Applicants: JAPAN AGENCY FOR MEDICAL RESEARCH AND DEVELOPMENT
国立研究開発法人日本医療研究開発機構
NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION
国立研究開発法人医薬基盤・健康・栄養研究所
Inventors: OBIKA Satoshi
小比賀 聡
KASAHARA Yuya
笠原 勇矢
TAKEUCHI Kosei
武内 恒成
Title: ANTISENSE NUCLEIC ACID FOR INHIBITING BIOSYNTHESIS OF CHONDROITIN SULFATE
Abstract:
The present invention provides an antisense oligonucleotide for inhibiting biosynthesis of chondroitin sulfate. This antisense oligonucleotide has at least one modified nucleotide that inhibits expression of chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGalNAcT1) gene and/or chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGalNAcT2) gene.