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1. (WO2018178996) IMPROVED PROCESS FOR THE PREPARATION OF PIRFENIDONE

Pub. No.:    WO/2018/178996    International Application No.:    PCT/IN2017/050243
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Tue Jun 20 01:59:59 CEST 2017
IPC: C07D 213/64
Applicants: NATCO PHARMA LIMITED
Inventors: SUTHRAPU, Sashikanth
TANKASALA, Naveena
ANDRU, Veman Reddy
KARICHETI, Maruthinath
RAVI, Janaki Rama Rao
KONAKANCHI, Durga Prasad
MUDDASANI, Pulla Reddy
NANNAPANENI, Venkaiah Chowdary
Title: IMPROVED PROCESS FOR THE PREPARATION OF PIRFENIDONE
Abstract:
The present invention relates to improved process for the production of Pirfenidone which is comprises reacting the compound of 5-methyl-2(1H)-pyridone of formula (III) with bromobenzene (IV) in polar solvent, in presence of base and activated Cu powder to obtain the compound of formula (I). The present invention is also related to purification of Pirfenidone.