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1. (WO2018178994) COMPOSITIONS AND METHODS SPECIFICALLY TARGETING THE APOLIPOPROTEIN E4 (APOE4) AND USES THEREOF IN APOE4 ASSOCIATED CONDITIONS

Pub. No.:    WO/2018/178994    International Application No.:    PCT/IL2018/050381
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 30 01:59:59 CEST 2018
IPC: A61K 48/00
C12N 15/85
C12Q 1/68
Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventors: OFFEN, Daniel
RABINOWITZ, Roy
BEN-ZUR, Tali
MICHAELSON, Daniel
Title: COMPOSITIONS AND METHODS SPECIFICALLY TARGETING THE APOLIPOPROTEIN E4 (APOE4) AND USES THEREOF IN APOE4 ASSOCIATED CONDITIONS
Abstract:
The invention relates to improvement and therapy of neuronal conditions involving neurodegenerative, inflammatory and vascular conditions. More specifically, the invention provides compositions and methods for specific targeted elimination of apolipoprotein E4 (apoE4), and uses thereof in the treatment and prevention of ApoE4 associated conditions.