Search International and National Patent Collections

1. (WO2018178944) SALT FORMS OF AMINO PYRAZINE PURINE BASED SELECTIVE KINASE INHIBITOR

Pub. No.:    WO/2018/178944    International Application No.:    PCT/IB2018/052222
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Sat Mar 31 01:59:59 CEST 2018
IPC: A61K 31/195
A61P 25/28
C07D 473/16
Applicants: FTG BIO LLC
Inventors: GARZON, Felix Tomas
HARSHA, Chaitra
PASHA, Mohammed Khalid
Title: SALT FORMS OF AMINO PYRAZINE PURINE BASED SELECTIVE KINASE INHIBITOR
Abstract:
The present invention relates to amino pyrazine purine compounds that are useful as kinase inhibitors. More particularly, the present invention relates to 5-(2-(8-Oxa-3-azabicyclo[octan- 3-yl)-9-(pentan-3-yl)-9H-purine-6-yl)pyrazin-2-amine compounds, including pharmaceutically acceptable salts thereof, method of preparations, pharmaceutical compositions containing these compounds and uses of these compounds in modulating phosphoinositide 3-kinase (PI3K-AKT), mammalian target of rapamycin (mTOR), DNA-PK and ATM kinase, and may be used as therapeutic agents or diagnostic probes and for the treatment of a number of proliferative conditions or disorders including tumours, cancers, haemaological and lymphatic malignancies, immunological and gene alterations disorders, inflammation, certain metabolic diseases, cardiovascular diseases, obesity, type 2 diabetes, anti-aging and neurological disorders.