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1. (WO2018178879) HYDROCODONE BASE AND METHODS FOR ITS PURIFICATION
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Pub. No.: WO/2018/178879 International Application No.: PCT/IB2018/052103
Publication Date: 04.10.2018 International Filing Date: 27.03.2018
IPC:
A61K 31/485 (2006.01) ,C07D 489/00 (2006.01) ,C07D 489/02 (2006.01) ,C07D 489/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
485
Morphinan derivatives, e.g. morphine, codeine
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
489
Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
489
Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
02
with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
489
Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
02
with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
04
Salts; Organic complexes
Applicants:
NORAMCO, INC. [US/US]; 500 Swedes Landing Road Wilmington, Delaware 19801, US
Inventors:
CARDOT, Jessica; US
SASINE, Joshua; US
NICHOLS, Paul; US
Agent:
SKELTON, Bryan L.; US
ALSTON & BIRD LLP; Alston & Bird LLP Bank of America Plaza 101 South Tryon Street, Suite 4000 Charlotte, North Carolina 28280-4000, US
SCHILLING, Stephen H.; US
KEITH, Jason A.; US
WEST, Christopher; US
CHANG, Cindy; US
Priority Data:
62/477,03527.03.2017US
Title (EN) HYDROCODONE BASE AND METHODS FOR ITS PURIFICATION
(FR) BASE D'HYDROCODONE ET PROCÉDÉS DE PURIFICATION DE CELLE-CI
Abstract:
(EN) A method of recovering a highly pure hydrocodone base from an impure hydrocodone preparation includes contacting the impure hydrocodone preparation with a weak acid in water to form a solution and adding a strong base to the solution in an amount sufficient to precipitate the pure hydrocodone base product. A highly pure hydrocodone base comprises less than 0.0025 wt% codeinone.
(FR) Un procédé de récupération d'une base d'hydrocodone très pure à partir d'une préparation d'hydrocodone impure comprend la mise en contact de la préparation d'hydrocodone impure avec un acide faible dans de l'eau pour former une solution et l'ajout d'une base forte à la solution dans une quantité suffisante pour précipiter le produit de base d'hydrocodone pur. Une base d'hydrocodone très pure comprend moins de 0,0025 % en poids de codéinone.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)