Described herein is a respiratory system 100, primarily to provide a mechanical insufflation/exsufflation therapy. The respiratory system includes a first pressure generating source 102, a second pressure generating source 104 and a primary valve 108 to switch between insufflation/positive pressure flow and exsufflation/negative pressure flow, and to generate oscillations alongside either of these cycles. Further, to generate oscillation along with the insufflation and exsufflation cycles, the respiratory system 100 can optionally employ a secondary valve 110 either on a fluidic path of the first pressure generating source 102 or on a fluidic path of the second pressure generating source 104. An interfacing assembly 106 acts as a fluidic conduit between the pressure generating sources and the patient. A control unit which forms a part of the system is configured to generate required pressurized flow and oscillations as per the user settings. The aforesaid valves can be manipulated into a plurality of orientations/positions, which are aligned and/or adjusted with respect to the respective pressure generating sources as per the therapy requirements.