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1. WO2018178691 - ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM

Publication Number WO/2018/178691
Publication Date 04.10.2018
International Application No. PCT/GB2018/050845
International Filing Date 28.03.2018
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C07D 405/06 (2006.01)
CPC
C07B 2200/13
C07D 405/06
Applicants
  • ASTEX THERAPEUTICS LIMITED [GB/GB]; 436 Cambridge Science Park Milton Road Cambridge Cambridgeshire CB4 0QA, GB
  • CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Angel Building 407 St. John Street London Greater London EC1V 4AD, GB
Inventors
  • HOWARD, Steven; GB
  • CONS, Benjamin, David; GB
  • ST. DENIS, Jeffrey, David; GB
  • GRIFFITHS-JONES, Charlotte, Mary; GB
  • HISCOCK, Steven, Douglas; GB
  • HOLVEY, Rhian, Sara; GB
  • BURNS, Alan, Richard; GB
  • COUSIN, David; GB
  • DEXTER, Hannah, Louise; GB
  • PARRA, Guillaume, François; GB
  • WATTS, John, Paul; GB
  • JEWELL, Robert; GB
  • STOCKWELL, Jennifer, Ann; GB
  • HIRST, Kim, Louise; GB
  • LEMASSON, Isabelle, Anne; GB
  • NASH, David, John; GB
  • OSBORNE, James, Daniel; GB
  • PRIEDE, Jonas, Calleja; GB
  • RICHARDS, Nicholas, Paul; GB
  • DUMAS, Aaron, Michael; GB
  • BISHOP, Brian, Christopher; GB
  • PARRY-JONES, David; GB
  • SCOTT, Jeremy, Peter; GB
  • SHANMUGHAM, Meenakshi, Sundaram; GB
  • MULLENS, Peter, Richard; GB
  • LATHBURY, David, Charles; GB
  • DIXON, Darren, James; GB
  • GAUNT, Matthew, James; GB
Agents
  • ELKINGTON AND FIFE LLP; Thavies Inn House 3-4 Holborn Circus London Greater London EC1N 2HA, GB
Priority Data
1704965.128.03.2017GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM
(FR) INHIBITEURS ISOINDOLINONE DE L'INTERACTION MDM2-P53 ET PROCÉDÉS DE PRÉPARATION DE CES DERNIERS
Abstract
(EN)
The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1- (oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4- chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H- isoindol-2-yl]-2-methylpropanoic acid and its salts.
(FR)
L'invention concerne des procédés de préparation de dérivés d'isoindolin-1-one, et en particulier des procédés de préparation d'acide (2S,3S)-3-(4-chlorophényl)-3-[(1R)-1-(4-chlorophényl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-méthoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-méthylpropanoïque. L'invention concerne également des formes cristallines du composé acide (2S,3S)-3-(4-chlorophényl)-3-[(1R)-1-(4-chlorophényl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-méthoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-méthylpropanoïque et de ses sels.
Also published as
EP2018715926
Latest bibliographic data on file with the International Bureau