Search International and National Patent Collections

1. (WO2018178691) ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM

Pub. No.:    WO/2018/178691    International Application No.:    PCT/GB2018/050845
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Thu Mar 29 01:59:59 CEST 2018
IPC: C07D 405/06
Applicants: ASTEX THERAPEUTICS LIMITED
CANCER RESEARCH TECHNOLOGY LIMITED
Inventors: HOWARD, Steven
CONS, Benjamin, David
ST. DENIS, Jeffrey, David
GRIFFITHS-JONES, Charlotte, Mary
HISCOCK, Steven, Douglas
HOLVEY, Rhian, Sara
BURNS, Alan, Richard
COUSIN, David
DEXTER, Hannah, Louise
PARRA, Guillaume, François
WATTS, John, Paul
JEWELL, Robert
STOCKWELL, Jennifer, Ann
HIRST, Kim, Louise
LEMASSON, Isabelle, Anne
NASH, David, John
OSBORNE, James, Daniel
PRIEDE, Jonas, Calleja
RICHARDS, Nicholas, Paul
DUMAS, Aaron, Michael
BISHOP, Brian, Christopher
PARRY-JONES, David
SCOTT, Jeremy, Peter
SHAUNMUGHAM, Meenakshi, Sundaram
MULLENS, Peter, Richard
LATHBURY, David, Charles
DIXON, Darren, James
GAUNT, Matthew, James
Title: ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM
Abstract:
The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1- (oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4- chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H- isoindol-2-yl]-2-methylpropanoic acid and its salts.