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1. (WO2018178691) ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM
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Pub. No.: WO/2018/178691 International Application No.: PCT/GB2018/050845
Publication Date: 04.10.2018 International Filing Date: 28.03.2018
IPC:
C07D 405/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
Applicants:
ASTEX THERAPEUTICS LIMITED [GB/GB]; 436 Cambridge Science Park Milton Road Cambridge Cambridgeshire CB4 0QA, GB
CANCER RESEARCH TECHNOLOGY LIMITED [GB/GB]; Angel Building 407 St. John Street London Greater London EC1V 4AD, GB
Inventors:
HOWARD, Steven; GB
CONS, Benjamin, David; GB
ST. DENIS, Jeffrey, David; GB
GRIFFITHS-JONES, Charlotte, Mary; GB
HISCOCK, Steven, Douglas; GB
HOLVEY, Rhian, Sara; GB
BURNS, Alan, Richard; GB
COUSIN, David; GB
DEXTER, Hannah, Louise; GB
PARRA, Guillaume, François; GB
WATTS, John, Paul; GB
JEWELL, Robert; GB
STOCKWELL, Jennifer, Ann; GB
HIRST, Kim, Louise; GB
LEMASSON, Isabelle, Anne; GB
NASH, David, John; GB
OSBORNE, James, Daniel; GB
PRIEDE, Jonas, Calleja; GB
RICHARDS, Nicholas, Paul; GB
DUMAS, Aaron, Michael; GB
BISHOP, Brian, Christopher; GB
PARRY-JONES, David; GB
SCOTT, Jeremy, Peter; GB
SHAUNMUGHAM, Meenakshi, Sundaram; GB
MULLENS, Peter, Richard; GB
LATHBURY, David, Charles; GB
DIXON, Darren, James; GB
GAUNT, Matthew, James; GB
Agent:
ELKINGTON AND FIFE LLP; Thavies Inn House 3-4 Holborn Circus London Greater London EC1N 2HA, GB
Priority Data:
1704965.128.03.2017GB
Title (EN) ISOINDOLINONE INHIBITORS OF THE MDM2-P53 INTERACTION AND PROCESS FOR MAKING THEM
(FR) INHIBITEURS ISOINDOLINONE DE L'INTERACTION MDM2-P53 ET PROCÉDÉS DE PRÉPARATION DE CES DERNIERS
Abstract:
(EN) The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1- (oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4- chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H- isoindol-2-yl]-2-methylpropanoic acid and its salts.
(FR) L'invention concerne des procédés de préparation de dérivés d'isoindolin-1-one, et en particulier des procédés de préparation d'acide (2S,3S)-3-(4-chlorophényl)-3-[(1R)-1-(4-chlorophényl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-méthoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-méthylpropanoïque. L'invention concerne également des formes cristallines du composé acide (2S,3S)-3-(4-chlorophényl)-3-[(1R)-1-(4-chlorophényl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-méthoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-méthylpropanoïque et de ses sels.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)