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1. (WO2018178679) COMBINATION OF ISOINDOLINONE DERIVATIVES WITH SGI-110

Pub. No.:    WO/2018/178679    International Application No.:    PCT/GB2018/050832
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Thu Mar 29 01:59:59 CEST 2018
IPC: C07D 401/06
A61K 31/4035
A61K 31/708
C07D 403/06
C07D 405/06
C07D 405/10
C07D 405/12
C07H 19/207
C07C 403/12
C07D 209/46
A61P 35/00
Applicants: ASTEX THERAPEUTICS LIMITED
CANCER RESEARCH TECHNOLOGY LIMITED
Inventors: CHESSARI, Gianni
LYONS, John Francis
Title: COMBINATION OF ISOINDOLINONE DERIVATIVES WITH SGI-110
Abstract:
The invention provides a combination comprising: (i) a compound of formula (Io) : (Io) or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims; and (ii) a compound which is SGI-110 (SGI-110) or a tautomer or a solvate or a pharmaceutically acceptable salt thereof. Also provided are pharmaceutical compositions containing the combinations and medical uses of the combinations.