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1. (WO2018178668) A COMBINATION FOR USE IN THE TREATMENT OF LUNG CANCER
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Pub. No.: WO/2018/178668 International Application No.: PCT/GB2018/050820
Publication Date: 04.10.2018 International Filing Date: 28.03.2018
IPC:
A61K 45/06 (2006.01) ,A61K 31/485 (2006.01) ,A61K 31/592 (2006.01) ,A61K 31/593 (2006.01) ,A61K 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
485
Morphinan derivatives, e.g. morphine, codeine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
59
Compounds containing 9,10-seco-cyclopenta[a]hydro- phenanthrene ring systems
592
9,10-Secoergostane derivatives, e.g. ergocalciferol, vitamin D2
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
59
Compounds containing 9,10-seco-cyclopenta[a]hydro- phenanthrene ring systems
593
9,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
Applicants: LDN PHARMA LIMITED[GB/GB]; Locke Lord (UK) Llp 201 Bishopsgate London Greater London EC1M 3AB, GB
Inventors: DALGLEISH, Angus; GB
LUI, Wai; GB
Agent: GILL JENNINGS & EVERY LLP; The Broadgate Tower 20 Primrose Street London EC2A 2ES, GB
JAPPY, John; GB
Priority Data:
1704909.928.03.2017GB
Title (EN) A COMBINATION FOR USE IN THE TREATMENT OF LUNG CANCER
(FR) ASSOCIATION DESTINÉE À ÊTRE UTILISÉE DANS LE TRAITEMENT DU CANCER DU POUMON
Abstract:
(EN) The invention is based on the finding that co-administration of 6-β-naltrexol alongside vitamin D together with a chemotherapeutic agent, results in a further reduction in lung cancer cell growth. The combination of 6-β-naltrexol with vitamin D results in a greater decrease in the growth of cancer cells compared to the sum of the effects of each agent when administered in isolation.
(FR) L'invention repose sur le résultat montrant que la co-administration de 6-β-naltrexol et de vitamine D conjointement à un agent chimiothérapeutique entraîne une inhibition accrue de la croissance des cellules du cancer du poumon. L'association du 6-β-naltrexol et de la vitamine D entraîne une diminution plus importante de la croissance des cellules cancéreuses en comparaison avec la somme des effets de chacun des agents administrés seuls.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)