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1. (WO2018178396) BISPECIFIC ANTI-CD37 ANTIBODIES, MONOCLONAL ANTI-CD37 ANTIBODIES AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/178396    International Application No.:    PCT/EP2018/058479
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Apr 04 01:59:59 CEST 2018
IPC: C07K 16/28
A61P 35/00
Applicants: GENMAB HOLDING B.V.
Inventors: OOSTINDIE, Simone
BEURSKENS, Frank
BREIJ, Esther
VAN DEN BRINK, Edward
HOLLENSTEIN, Andreas
OVERDIJK, Marije
LINDORFER, Margaret
TAYLOR, Ronald
PARREN, Paul
VAN DER HORST, Hilma
E.D. CHAMULEAU, Martine
MUTIS, Tuna
Title: BISPECIFIC ANTI-CD37 ANTIBODIES, MONOCLONAL ANTI-CD37 ANTIBODIES AND METHODS OF USE THEREOF
Abstract:
CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.