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1. (WO2018178301) COMPANION DIAGNOSICS FOR LEUKEMIA TREATMENT

Pub. No.:    WO/2018/178301    International Application No.:    PCT/EP2018/058220
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 30 01:59:59 CEST 2018
IPC: C12Q 1/6886
Applicants: JOHANN WOLFGANG GOETHE-UNIVERSITÄT FRANKFURT AM MAIN
Inventors: OELLERICH, Thomas
SERVE, Hubert
MOHR, Sebastian
DOEBELE, Carmen
Title: COMPANION DIAGNOSICS FOR LEUKEMIA TREATMENT
Abstract:
The present invention pertains to a method for detecting whether a cancer disease in a subject is susceptible to a treatment with a Spleen Tyrosine Kinase (SYK) inhibitor by determining the amount or level of a biomarker selected from Hoxa9/Meis1, PU.1 and miR146a in a biological sample from the subject. The invention provides novel treatment approaches based on the detection of the differential expression of the above biomarkers using SYK inhibitors. Also provided are diagnostic kits, and combined therapeutic and diagnostic kits for use in the inventive methods.