Search International and National Patent Collections

1. (WO2018178260) METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REDUCING PERSISTENCE AND EXPRESSION OF EPISOMAL VIRUSES

Pub. No.:    WO/2018/178260    International Application No.:    PCT/EP2018/058124
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 30 01:59:59 CEST 2018
IPC: A61K 31/4155
A61K 31/4192
A61K 31/42
A61K 31/422
A61K 31/496
A61K 31/55
A61P 31/12
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
ENS - ECOLE NORMALE SUPÉRIEURE DE LYON
UNIVERSITÉ CLAUDE BERNARD LYON 1
Inventors: LOTTEAU, Vincent
ANDRE, Patrice
Title: METHODS AND PHARMACEUTICAL COMPOSITIONS FOR REDUCING PERSISTENCE AND EXPRESSION OF EPISOMAL VIRUSES
Abstract:
The inventors surprisingly found that FXR plays a determinant role in the maintenance of viral episome in cells from tissues that are not specialized in bile salt synthesis and transport as the liver or the intestine. In particular, the inventors show that FXR agonist could be suitable for inhibiting the replication of viruses (e.g. BKV and HIV-1) that persist in the cell in an episomal and extrachromosomal form of DNA. Accordingly the present invention relates to a method of reducing persistence and expression of an episomal virus in a subject in need thereof comprising administrating to the subject a therapeutically effective amount of a FXR agonist.