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1. (WO2018178253) PHARMACEUTICAL COMPOSITIONS FOR USE IN THE TREATMENT OF CARDIOVASCULAR CALCIFICATION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/178253 International Application No.: PCT/EP2018/058115
Publication Date: 04.10.2018 International Filing Date: 29.03.2018
IPC:
A61K 31/00 (2006.01) ,A61K 31/198 (2006.01) ,A61K 31/255 (2006.01) ,C12Q 1/42 (2006.01) ,A61P 9/10 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
195
having an amino group
197
the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198
Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
255
of sulfoxy acids or sulfur analogues thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
34
involving hydrolase
42
involving phosphatase
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)[FR/FR]; 101, rue de Tolbiac 75013 Paris, FR
UNIVERSITÉ DE ROUEN NORMANDIE[FR/FR]; 76130 Mont-Saint-Aignan, FR
UNIVERSITÉ DE PICARDIE JULES VERNE[FR/FR]; Chemin du Thil 80000 Amiens, FR
CENTRE HOSPITALIER UNIVERSITAIRE DE ROUEN[FR/FR]; 76000 Rouen, FR
CENTRE HOSPITALIER UNIVERSITAIRE D'AMIENS[FR/FR]; Hôpital Nord, 2 Place Victor Pauchet, 80000 Amiens, FR
Inventors: BELLIEN, Jérémy; FR
SIX, Isabelle; FR
MENTAVERRI, Romuald; FR
KAMEL, Saïd; FR
Agent: COLLIN, Matthieu; FR
Priority Data:
17305370.330.03.2017EP
17306561.610.11.2017EP
Title (EN) PHARMACEUTICAL COMPOSITIONS FOR USE IN THE TREATMENT OF CARDIOVASCULAR CALCIFICATION
(FR) COMPOSITIONS PHARMACEUTIQUES DESTINÉES À ÊTRE UTILISÉES DANS LE TRAITEMENT DE LA CALCIFICATION CARDIOVASCULAIRE
Abstract:
(EN) The inventors demonstrate that the phosphatase and hydrolase domains of soluble expoxide hydrolase (sEH) regulate the cardiovascular calcification process and revealed that inhibition of the phosphatase domain of sEH could represent a new pharmacological target in the prevention of cardiovascular calcification. The present invention thus relates to a therapeutically effective amount of an inhibitor of phosphatase activity of soluble epoxide hydrolase for use in a method of treating cardiovascular calcification in a subject in need thereof.
(FR) Les inventeurs démontrent que les domaines phosphatase et hydrolase d'époxyde hydrolase soluble (EHs) régulent le processus de calcification cardiovasculaire et ont révélé que l'inhibition du domaine phosphatase de l’EHs pourrait représenter une nouvelle cible pharmacologique dans la prévention de la calcification cardiovasculaire. La présente invention concerne ainsi une quantité thérapeutiquement efficace d'un inhibiteur de l'activité phosphatase d'époxyde hydrolase soluble destinée à être utilisée dans un procédé de traitement de calcification cardiovasculaire chez un sujet en ayant besoin.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)