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1. (WO2018178129) CRYSTALLINE FORM OF (S)-[2-CHLORO-4-FLUORO-5-(7-MORPHOLIN-4-YLQUINAZOLIN-4-YL)PHENYL]-(6-METHOXY-PYRIDAZIN-3-YL)-METHANOL
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Pub. No.: WO/2018/178129 International Application No.: PCT/EP2018/057869
Publication Date: 04.10.2018 International Filing Date: 28.03.2018
IPC:
C07D 403/14 (2006.01) ,A61K 31/506 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
MERCK PATENT GMBH [DE/DE]; Frankfurter Strasse 250 64293 Darmstadt, DE
Inventors:
LANGE, Michael; DE
KUEHN, Clemens; DE
FUCHSS, Thomas; DE
MAILLARD, David; DE
BREUNING, Marcel; DE
POMA, Marco; IT
BURINI, Edoardo; IT
Priority Data:
17163821.630.03.2017EP
Title (EN) CRYSTALLINE FORM OF (S)-[2-CHLORO-4-FLUORO-5-(7-MORPHOLIN-4-YLQUINAZOLIN-4-YL)PHENYL]-(6-METHOXY-PYRIDAZIN-3-YL)-METHANOL
(FR) FORME CRISTALLINE DE (S)-[2-CHLORO-4-FLUORO-5-(7-MORPHOLIN-4-YLQUINAZOLIN-4-YL)PHÉNYL]-(6-MÉTHOXY-PYRIDAZIN-3-YL)-MÉTHANOL
Abstract:
(EN) The present invention relates to a crystalline form of (S)-[2-chloro-4- fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxy-pyridazin- 3-yl)methanol, as well as a method of making same, and pharmaceutical compositions and uses thereof.
(FR) La présente invention concerne une forme cristalline de (S)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phényl]-(6-méthoxy-pyridazin-3-yl)méthanol, ainsi qu'un procédé de fabrication de ceux-ci, des compositions pharmaceutiques et leurs utilisations.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)