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1. (WO2018178074) TRIMERIC ANTIGEN BINDING MOLECULES SPECIFIC FOR A COSTIMULATORY TNF RECEPTOR

Pub. No.:    WO/2018/178074    International Application No.:    PCT/EP2018/057767
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Mar 28 01:59:59 CEST 2018
IPC: C07K 14/705
A61K 38/17
A61K 39/395
C07K 16/28
C07K 16/30
C12N 15/62
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: AMANN, Maria
BRUENKER, Peter
CLAUS, Christina
FERRARA KOLLER, Claudia
GRAU-RICHARDS, Sandra
KLEIN, Christian
MOESSNER, Ekkehard
UMAÑA, Pablo
Title: TRIMERIC ANTIGEN BINDING MOLECULES SPECIFIC FOR A COSTIMULATORY TNF RECEPTOR
Abstract:
The invention relates to novel trimeric antigen binding molecules comprising three fusion polypeptides, each of the three fusion polypeptides comprising (a) a moiety capable of specific binding to a costimulatory TNF receptor family member, (b) a trimerization domain derived from human cartilage matrix protein (huCMP) of amino acid sequence of SEQ ID NO: l, and (c) a moiety capable of specific binding to a target cell antigen, and to methods of producing these molecules and to methods of using the same.