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1. (WO2018178071) METHOD FOR PREDICTING THE THERAPEUTIC RESPONSE TO ANTIPSYCHOTIC DRUGS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/178071 International Application No.: PCT/EP2018/057761
Publication Date: 04.10.2018 International Filing Date: 27.03.2018
IPC:
C12Q 1/6876 (2018.01) ,G01N 33/68 (2006.01)
[IPC code unknown for C12Q 1/6876]
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS[ES/ES]; C/ Serrano, 117 28006 Madrid, ES
UNIVERSIDAD DE CANTABRIA[ES/ES]; Avda. de los Castros, s/n 39005 Santander, ES
CIBER CENTRO DE INVESTIGACION BIOMEDICA EN RED[ES/ES]; C/ Monforte de Lemos, 3.5 Pabellón 11 28029 Madrid, ES
SERVICIO CANTABRO DE SALUD[ES/ES]; Avda. Cardenal Herrara Oria, s/n 39011 Santander, ES
Inventors: SAINZ MAZA, Jesús Vicente; ES
CRESPO FACORRO, Benedicto; ES
Agent: PONS ARIÑO, Ángel; ES
Priority Data:
P 20173046429.03.2017ES
Title (EN) METHOD FOR PREDICTING THE THERAPEUTIC RESPONSE TO ANTIPSYCHOTIC DRUGS
(FR) PROCÉDÉ DE PRÉDICTION DE LA RÉPONSE THÉRAPEUTIQUE À DES MÉDICAMENTS ANTIPSYCHOTIQUES
Abstract:
(EN) The present invention discloses a method for predicting, before treatment, the individual clinical response to antipsychotic medication in subjects suffering from psychosis. This method is based on a gene expression profile that is useful to predict the therapeutic response to antipsychotics in drug-naïve patients. Particularly, the gene signature proposed in the invention comprises six-genes (SLC9A3, HMOX1, SLC22A16, LOC284581, PF4V1 and GSTT1) which expression profile, preferably measured in blood samples collected from the patient, provides useful information to predict the clinical response to antipsychotics in psychotic patients, more preferably in schizophrenia patients, before treatment.
(FR) La présente invention concerne un procédé de prédiction, avant le traitement, de la réponse clinique individuelle à un médicament antipsychotique chez des sujets souffrant de psychose. Ce procédé est basé sur un profil d'expression génique qui est utile pour prédire la réponse thérapeutique à des antipsychotiques chez des patients non encore traités. En particulier, la signature génique proposée dans l'invention comprend six gènes (SLC9A3, HMOX1, SLC22A16, LOC284581, PF4V1 et GSTT1), lequel profil d'expression, de préférence mesuré dans des échantillons de sang recueillis à partir du patient, fournit des informations utiles pour prédire la réponse clinique à des antipsychotiques chez des patients psychotiques, plus préférablement chez des patients atteints de schizophrénie, avant le traitement.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)