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|1. (WO2018177889) NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS|
BAYER PHARMA AKTIENGESELLSCHAFT
|Title:||NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS|
The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).