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1. (WO2018177889) NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS

Pub. No.:    WO/2018/177889    International Application No.:    PCT/EP2018/057326
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Mar 23 00:59:59 CET 2018
IPC: C07D 239/30
C07D 498/08
C07D 498/18
C07D 213/61
A61K 31/519
A61P 35/00
A61P 9/00
Applicants: BAYER AKTIENGESELLSCHAFT
BAYER PHARMA AKTIENGESELLSCHAFT
Inventors: LÜCKING, Ulrich
HOG, Daniel
CHRIST, Clara
SACK, Ulrike
SIEGEL, Franziska
LIENAU, Philip
WERBECK, Nicolas
Title: NOVEL PTEFB INHIBITING MACROCYCLIC COMPOUNDS
Abstract:
The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).