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1. (WO2018177784) NEW TRIAZINE SUBSTANCE FOR USE IN THE TREATMENT OF CANCER, SPECIFICALLY IN THE TREATMENT OF NON-SMALL CELL CANCER
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Pub. No.: WO/2018/177784 International Application No.: PCT/EP2018/056817
Publication Date: 04.10.2018 International Filing Date: 19.03.2018
IPC:
C07D 251/18 (2006.01) ,A61K 31/53 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
251
Heterocyclic compounds containing 1,3,5-triazine rings
02
not condensed with other rings
12
having three double bonds between ring members or between ring members and non-ring members
14
with hydrogen or carbon atoms directly attached to at least one ring carbon atom
16
to only one ring carbon atom
18
with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
53
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants: UNIVERSITE DE NANTES[FR/FR]; 1, Quai de Tourville 44000 NANTES, FR
Inventors: ROUSSAKIS, Christos; FR
ROBERT, Jean-Michel; FR
Agent: LE CLOIREC, Claudine; FR
GODINEAU, Valérie; FR
Priority Data:
17305361.229.03.2017EP
Title (EN) NEW TRIAZINE SUBSTANCE FOR USE IN THE TREATMENT OF CANCER, SPECIFICALLY IN THE TREATMENT OF NON-SMALL CELL CANCER
(FR) NOUVELLE SUBSTANCE TRIAZINIQUE DESTINÉE À ÊTRE UTILISÉE DANS LE TRAITEMENT DU CANCER, PLUS PRÉCISÉMENT DANS LE TRAITEMENT DU CANCER NON À PETITES CELLULES
Abstract:
(EN) Substance of formula (I) for use as a medicament, wherein A is a [ -(CH2)n- ] spacer, n being an integer comprised between 1 and 3, preferably between 1 and 2; Xm are m substituents, m being an integer comprised between 1 and 3, wherein X is chosen among CI, Br, OCH3 or SCH3; and R1, R2, R3 and R4 are chosen among hydrogen atoms or C1-C3 alkyl groups. This substance has an anti-proliferative action on tumor cells and may advantageously be for use in the treatment of non-small cell cancer, preferably for use in the treatment of non-small cell squamous carcinoma, and more preferably for use in the treatment of non-small cell lung cancer.
(FR) La substance de formule (I) est destinée à être utilisée en tant que médicament, A représentant un espaceur [-(CH2)n-] , n représentant un nombre entier compris entre 1 et 3, de préférence entre 1 et 2 ; Xm représente m substituants, m étant un nombre entier compris entre 1 et 3, X étant choisi parmi Cl, Br, OCH3 ou SCH3 ; et R1, R2, R3 et R4 sont choisis parmi les atomes d'hydrogène ou les groupes alkyle en C1-C3. Cette substance a une action antiproliférative sur les cellules tumorales et peut être avantageusement utilisée dans le traitement du cancer non à petites cellules, de préférence pour une utilisation dans le traitement d'un carcinome squameux non à petites cellules et plus préférablement pour une utilisation dans le traitement du cancer du poumon non à petites cellules.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)