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1. (WO2018177276) A CRYSTAL FORM OF TUBULIN INHIBITOR

Pub. No.:    WO/2018/177276    International Application No.:    PCT/CN2018/080617
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Mar 28 01:59:59 CEST 2018
IPC: C07D 403/06
A61K 31/496
A61P 35/00
Applicants: SHENZHEN NEPTUNUS PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD.
深圳海王医药科技研究院有限公司
Inventors: TANG, Tian
唐田
PENG, Jianghua
彭江华
JIN, Ruyi
靳如意
YANG, Jingan
杨经安
SHE, Qin
佘琴
SHI, Tao
石涛
Title: A CRYSTAL FORM OF TUBULIN INHIBITOR
Abstract:
The present invention provides an A crystal form of (3Z,6Z)-3-[((E)-3-(5-tert-butyl)-1H-imidazol-4-yl)methylene]-6-((E)-3-(3-fluorophenyl)-2-propenylidene)piperazine-2,5-dione (VDA-1). The A crystal form has a stable morphology, a definite melting point, and good chemical stability and is high-temperature resistant and suitable for pharmaceutical uses. The A crystal form can be used to treat a hyperproliferative disease.