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1. (WO2018177151) COMPOUNDS MODULATING ACTIVITY OF FARNESOID X RECEPTOR AND METHODS FOR THE USE THEREOF

Pub. No.:    WO/2018/177151    International Application No.:    PCT/CN2018/079472
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Tue Mar 20 00:59:59 CET 2018
IPC: C07C 233/59
C07D 333/38
A61K 31/196
A61K 31/277
A61K 31/341
A61K 31/381
A61K 31/42
A61P 37/02
A61P 1/16
Applicants: XIAMEN UNIVERSITY
Inventors: LI, Yong
JIN, Lihua
ZHU, Yanlin
LU, Yi
WEI, Yijuan
YAO, Benqiang
XU, Shuangshuang
ZHENG, Xing
Title: COMPOUNDS MODULATING ACTIVITY OF FARNESOID X RECEPTOR AND METHODS FOR THE USE THEREOF
Abstract:
Compounds such as vidofludimus and its analogues useful in modulating the activity of nuclear receptor FXR. Also disclosed are the methods for treating FXR-mediated disease or process in a mammal, comprising administering to the mammal a therapeutically effective amount of a compound claimed, wherein the FXR-mediated disease or condition linked to chronic liver diseases such as nonalcoholic fatty liver disease and nonalcoholic steatohepatitis, inflammatory diisease such as rheumatoid arthritis and inflammatory bowel disease, cardiovascular diseases, or metabolic diseases such as diabetes and obesity.