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1. (WO2018177114) SALICYLIC ACID-BASED FUMARATE DERIVATIVE AND USE IN TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES

Pub. No.:    WO/2018/177114    International Application No.:    PCT/CN2018/078618
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Sat Mar 10 00:59:59 CET 2018
IPC: C07C 67/29
C07C 69/60
A61K 31/222
A61P 25/16
A61P 25/00
Applicants: CHONGQING NEUROPARK BIRSCIENCE CO., LTD.
重庆纽源生物科技有限公司
Inventors: YANG, Lichuan
杨立川
THOMAS, Bobby
托马斯鲍比
GUO, Mingyue
郭明跃
Title: SALICYLIC ACID-BASED FUMARATE DERIVATIVE AND USE IN TREATMENT OF PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES
Abstract:
The new compound provided by the applicant is a salicylic acid-based fumarate derivative having a general structural formula (A): wherein in the general structural formula (A), R1 is one of H+, Na+, K+ or NH4+, and R2 is an esterified product of fumaric acid. According to the experimental verification by the applicant, the salicylic acid-based fumarate derivative has the general structural formula formed by combining salicylic acid and fumaric acid via an esterification reaction. It is proven that such a compound has a good activity in the treatment of neurodegenerative diseases.