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1. (WO2018176103) "CHIMERIC MOLECULES AND USES THEREOF"
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Pub. No.: WO/2018/176103 International Application No.: PCT/AU2018/050299
Publication Date: 04.10.2018 International Filing Date: 29.03.2018
IPC:
C07K 19/00 (2006.01) ,C07K 14/11 (2006.01) ,C07K 14/115 (2006.01) ,C07K 14/15 (2006.01) ,C07K 14/165 (2006.01) ,C07K 14/08 (2006.01) ,A61P 31/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
11
Orthomyxoviridae, e.g. influenza virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
115
Paramyxoviridae, e.g. parainfluenza virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
15
Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
165
Coronaviridae, e.g. avian infectious bronchitis virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
Applicants: THE UNIVERSITY OF QUEENSLAND[AU/AU]; The University of Queensland St Lucia, Queensland 4072, AU
Inventors: CHAPPELL, Keith, Joseph; AU
WATTERSON, Daniel; AU
YOUNG, Paul, Robert; AU
Agent: DAVIES COLLISON CAVE PTY LTD; 10/301 Coronation Drive Milton, Queensland 4064, AU
Priority Data:
201790115230.03.2017AU
Title (EN) "CHIMERIC MOLECULES AND USES THEREOF"
(FR) MOLÉCULES CHIMÉRIQUES ET UTILISATIONS ASSOCIÉES
Abstract:
(EN) Disclosed are chimeric polypeptides based on viral membrane fusion proteins. More particularly, the present invention discloses chimeric polypeptides that comprise a virion surface exposed portion of a viral fusion protein and a heterologous structure- stabilizing moiety, and to complexes of those chimeric polypeptides. The present invention also discloses the use of these complexes in compositions and methods for eliciting an immune response to a fusion protein of an enveloped virus, or complex of the fusion protein, and/or for treating or preventing an enveloped virus infection. The present invention further discloses the use of the heterologous structure-stabilizing moiety for oligomerizing heterologous molecules of interest.
(FR) L'invention concerne des polypeptides chimériques basés sur des protéines de fusion de membrane virale. Plus particulièrement, la présente invention concerne des polypeptides chimériques qui comprennent une partie de la surface exposée de virion d'une protéine de fusion virale et une fraction de stabilisation de structure hétérologue, ainsi que des complexes de ces polypeptides chimériques. La présente invention concerne également l'utilisation de ces complexes dans des compositions et des procédés pour déclencher une réponse immunitaire à une protéine de fusion d'un virus à enveloppe, ou d'un complexe de la protéine de fusion, et/ou pour traiter ou prévenir une infection par le virus à enveloppe. La présente invention concerne en outre l'utilisation de la fraction de stabilisation de structure hétérologue pour l'oligomérisation de molécules hétérologues d'intérêt.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)