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1. (WO2018176089) SCREENING METHODS

Pub. No.:    WO/2018/176089    International Application No.:    PCT/AU2018/050283
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Wed Mar 28 01:59:59 CEST 2018
IPC: G01N 33/53
C07K 16/00
Applicants: GARVAN INSTITUTE OF MEDICAL RESEARCH
Inventors: CHRIST, Daniel
CHRISTIE, Mary
Title: SCREENING METHODS
Abstract:
The present disclosure generally relates to proteins containing immunoglobulin light chain variable region homodimers, to methods of providing such proteins and to various uses of such proteins. In one example, the disclosure provides a method for screening a plurality of immunoglobulin homodimers, each homodimer comprising two identical light chain variable domain monomers, wherein screening of the immunoglobulin homodimers comprises identifying homodimers that are capable of binding specifically to an antigen to form an immunoglobulin-antigen complex.