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1. (WO2018176075) CHIMERIC INSECT-SPECIFIC FLAVIVIRUSES

Pub. No.:    WO/2018/176075    International Application No.:    PCT/AU2017/050973
Publication Date: Fri Oct 05 01:59:59 CEST 2018 International Filing Date: Fri Sep 08 01:59:59 CEST 2017
IPC: C07K 19/00
C07K 14/18
A61K 38/17
A61K 39/12
A61K 39/42
A61P 31/14
G01N 33/53
C12N 7/02
C12N 7/04
Applicants: THE UNIVERSITY OF QUEENSLAND
Inventors: HALL, Roy
HOBSON-PETERS, Jody
Title: CHIMERIC INSECT-SPECIFIC FLAVIVIRUSES
Abstract:
Chimeric proteins that comprise one or more amino acid sequences of an insect- specific flavivirus and one or more other immunogenic proteins are provided. The chimeric proteins are suitably capable of forming virus particles. The chimeric protein and/or virus particle may be suitable for delivery to a subject to elicit an immune response to a pathogen and/or for diagnosis or detection of a pathogen. Also provided are nucleic acids and vectors encoding the chimeric proteins, and isolated chimeric insect-specific flaviviruses comprising the chimeric proteins and/or nucleic acids.