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1. (WO2018175340) REDUCED EXPOSURE CONJUGATES MODULATING THERAPEUTIC TARGETS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2018/175340 International Application No.: PCT/US2018/023174
Publication Date: 27.09.2018 International Filing Date: 19.03.2018
IPC:
A61K 47/60 (2017.01) ,A61P 11/00 (2006.01) ,A61P 1/00 (2006.01) ,A61P 17/00 (2006.01) ,A61P 27/02 (2006.01)
[IPC code unknown for A61K 47/60]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
Applicants:
SIENNA BIOPHARMACEUTICALS, INC. [US/US]; 30699 Russell Ranch Road, Suite 140 Westlake Village, California 91362, US
Inventors:
TRAVERSA, Silvio; US
BAGNOD, Raffaella; US
MAINERO, Valentina; US
HARRIS, Todd James; US
RAVA ROSSA, Luisa, Bertarione; US
Agent:
HEUBERGER, Benjamin, D.; US
Priority Data:
62/473,97220.03.2017US
62/473,97520.03.2017US
62/473,98220.03.2017US
62/501,56704.05.2017US
62/501,56804.05.2017US
62/501,65104.05.2017US
62/504,11110.05.2017US
62/590,11122.11.2017US
62/590,11922.11.2017US
62/590,13122.11.2017US
62/590,14822.11.2017US
62/634,69123.02.2018US
Title (EN) REDUCED EXPOSURE CONJUGATES MODULATING THERAPEUTIC TARGETS
(FR) CONJUGUÉS D’EXPOSITION RÉDUITE MODULANT DES CIBLES THÉRAPEUTIQUES
Abstract:
(EN) Disclosed herein are polymer conjugates comprising an active agent linked to a polymer, wherein the active agent comprises an inhibitor, antagonist, or inverse agonist of a mediator of a therapeutic target associated with a condition, including for example, an ophthalmic condition, a dermatological condition, an inflammatory bowel disease or other gastrointestinal conditions and a respiratory condition. The disclosed polymer conjugates reduce exposure of the active agent at non-target sites.
(FR) La présente invention concerne des conjugués polymères comprenant un principe actif lié à un polymère, le principe actif comprenant un inhibiteur, un antagoniste ou un agoniste inverse d'un médiateur d'une cible thérapeutique associée à un état pathologique, comprenant, par exemple, un état pathologique ophtalmique, une affection dermatologique, une maladie inflammatoire de l’intestin ou d'autres états pathologiques gastro-intestinaux et un état pathologique respiratoire. Les conjugués polymères selon l'invention réduisent l'exposition du principe actif au niveau de sites non ciblés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)