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1. (WO2018169983) METHODS OF MODULATING EXPRESSION OF TARGET NUCLEIC ACID SEQUENCES IN A CELL
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Pub. No.:
WO/2018/169983
International Application No.:
PCT/US2018/022220
Publication Date:
20.09.2018
International Filing Date:
13.03.2018
IPC:
C12N 9/22
(2006.01) ,
C12N 15/864
(2006.01)
C
CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
22
Ribonucleases
C
CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
864
Parvoviral vectors
Applicants:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE
[US/US]; 17 Quincy Street Cambridge, Massachusetts 02138, US
Inventors:
VORA, Suhani D.
; US
CHAVEZ, Alejandro
; US
CHENG, Jing
; US
PRUITT, Benjamin W.
; US
Agent:
IWANICKI, John P.
; US
Priority Data:
62/470,538
13.03.2017
US
Title
(EN)
METHODS OF MODULATING EXPRESSION OF TARGET NUCLEIC ACID SEQUENCES IN A CELL
(FR)
PROCÉDÉS DE MODULATION DE L'EXPRESSION DE SÉQUENCES D'ACIDES NUCLÉIQUES CIBLES DANS UNE CELLULE
Abstract:
(EN)
The present disclosure provides methods and compositions of modulating expression of a target nucleic acid sequence in a cell. The method comprises introducing into the cell a nucleic acid sequence encoding a Cas9 fusion protein and a guide RNA, wherein the Cas9 fusion protein and the guide RNA are expressed and co-localize at a target site and modulate the expression of the target nucleic acid sequence.
(FR)
La présente invention concerne des procédés et des compositions de modulation de l'expression d'une séquence d'acide nucléique cible dans une cellule. Le procédé comprend l'introduction dans la cellule d'une séquence d'acide nucléique codant pour une protéine de fusion de Cas9 et un ARN guide, la protéine de fusion Cas9 et l'ARN guide étant exprimés et colocalisés au niveau d'un site cible et modulant l'expression de la séquence d'acide nucléique cible.
Designated States:
AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language:
English (
EN
)
Filing Language:
English (
EN
)