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1. WO2018167804 - NOVEL POLYMORPHS OF (5-[3-(3-HYDROXYPHENOXY)AZETIDIN-1-YL]-5-METHYL-2,2-DIPHENYLHEXANAMIDE HYDROCHLORIDE

Publication Number WO/2018/167804
Publication Date 20.09.2018
International Application No. PCT/IN2018/050148
International Filing Date 15.03.2018
IPC
C07D 205/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
205Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
A61P 11/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61K 31/397 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
397having four-membered rings, e.g. azetidine
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07D 205/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
205Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
Applicants
  • MYLAN LABORATORIES LIMITED [IN]/[IN]
Inventors
  • JETTI, Ramakoteswara Rao
  • INDUKURI, Anjaneyaraju
  • PILLI, Narasimha Murty
Agents
  • HASAN, Afzal
  • HASAN, Vatsala Singh
Priority Data
20174100896415.03.2017IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL POLYMORPHS OF (5-[3-(3-HYDROXYPHENOXY)AZETIDIN-1-YL]-5-METHYL-2,2-DIPHENYLHEXANAMIDE HYDROCHLORIDE
(FR) NOUVEAUX POLYMORPHES DE CHLORHYDRATE DE (5-[3-(3-HYDROXYPHÉNOXY) AZÉTIDIN-1-YL]-5-MÉTHYL-2,2-DIPHÉNYLHEXANAMIDE
Abstract
(EN)
The present disclosure provides solid forms of the hydrochloride salt of (5-[3-(3-Hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide (Compound-A). In particular, an amorphous form, an ethyl acetate solvate form, a methyl n-butyl ketone solvate form, an anisole solvate form, an isobutyl acetate solvate form, a n-butyl acetate solvate form, a toluene solvate form, a 4-methyl-2-pentanol solvate form, a n-propyl acetate solvate form, a xylene solvate form, Form VIII and Form IX of the salt are disclosed. Processes for the preparation of each of the disclosed forms are also provided.
(FR)
La présente invention concerne des formes solides du sel chlorhydrate de (5-[3- (3-hydroxyphénoxy)azétidin-1-yl]-5-méthyl-2,2-diphénylhexanamide (composé A). L'invention concerne en particulier une forme amorphe, une forme solvatée d'acétate d'éthyle, une forme solvatée de méthyl n-butyle cétone, une forme solvatée d'anisole, une forme solvatée d'acétate d'isobutyle, une forme solvatée d'acétate de n-butyle, une forme solvatée de toluène, une forme solvatée de 4-méthyl-2-pentanol, une forme solvatée d'acétate de n-propyle, une forme solvatée de xylène, une forme VIII et une forme IX du sel. L'invention concerne également des procédés de préparation de chacune des formes décrites.
Also published as
Latest bibliographic data on file with the International Bureau