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1. (WO2018167132) LYSYL OXIDASE LIKE-2 ASSAY
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Pub. No.: WO/2018/167132 International Application No.: PCT/EP2018/056364
Publication Date: 20.09.2018 International Filing Date: 14.03.2018
IPC:
C07K 16/40 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
40
against enzymes
Applicants: NORDIC BIOSCIENCE A/S[DK/DK]; Herlev Hovedgade 207 2730 Herlev, DK
Inventors: ORSNES-LEEMING, Diana; DK
KARSDAL, Morten; DK
NIELSEN, Signe, Holm; DK
Agent: BECK GREENER; 12 Fulwood Place London WC1V 6HR, GB
Priority Data:
1704206.016.03.2017GB
Title (EN) LYSYL OXIDASE LIKE-2 ASSAY
(FR) DOSAGE DE TYPE 2 DE LYSYL OXYDASE
Abstract:
(EN) The present invention relates to an antibody, wherein the antibody specifically binds to the N-terminus of Lysyl Oxidase Like-2 (LOXL2), and its use in a method of immunoassay for detecting or quantitating LOXL2 in a sample. The method may be used to evaluate LOXL2-associated diseases, and may also be used to evaluate the efficacy of anti-LOXL2 therapeutics.
(FR) La présente invention concerne un anticorps, l'anticorps se liant spécifiquement à l'extrémité N-terminale de la lysyl oxydase de type 2 (LOXL2), et son utilisation dans un procédé de dosage immunologique pour détecter ou quantifier la LOXL2 dans un échantillon. Le procédé peut être utilisé pour évaluer des maladies associées à LOXL2, et peut également être utilisé pour évaluer l'efficacité d'agents thérapeutiques anti-LOXL2.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)