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1. (WO2018167119) PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF THROMBOSIS IN PATIENTS SUFFERING FROM A MYELOPROLIFERATIVE NEOPLASM

Pub. No.:    WO/2018/167119    International Application No.:    PCT/EP2018/056333
Publication Date: Fri Sep 21 01:59:59 CEST 2018 International Filing Date: Thu Mar 15 00:59:59 CET 2018
IPC: A61K 31/00
A61K 31/17
C07K 16/28
A61P 7/02
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
UNIVERSITÉ DE BORDEAUX
CHU HÔPITAUX DE BORDEAUX
UNIVERSITÉ PARIS DIDEROT - PARIS 7
UNIVERSITÉ PARIS XIII PARIS-NORD
Inventors: JAMES, Chloé
COUFFINHAL, Thierry
GOURDOU-LATYSZENOK, Virginie
GUY, Alexandre
JANDROT-PERRUS, Martine
Title: PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF THROMBOSIS IN PATIENTS SUFFERING FROM A MYELOPROLIFERATIVE NEOPLASM
Abstract:
Thrombosis is the main cause of morbidity and mortality in patients with JAK2V617F positive myeloproliferative neoplasms (MPN). Recent works reported the presence of JAK2V617F in endothelial cells in some MPN patients. Here, the inventors show that JAK2V617F endothelial cells promote thrombosis through induction of endothelial P-selectin expression and thus demonstrate that P-selectin blockade was sufficient to reduce the increased propensity of thrombosis. Accordingly the present invention relates to a method of treating thrombosis in a patient suffering from a myeloproliferative neoplasm comprising administering to the patient a therapeutically effective amount of a P-selectin antagonist.