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1. (WO2018167001) HETEROCYCLIC COMPOUNDS USEFUL AS DUAL ATX/CA INHIBITORS

Pub. No.:    WO/2018/167001    International Application No.:    PCT/EP2018/056140
Publication Date: Fri Sep 21 01:59:59 CEST 2018 International Filing Date: Wed Mar 14 00:59:59 CET 2018
IPC: C07D 401/14
C07D 405/14
A61K 31/397
A61K 31/4025
A61K 31/496
C07D 401/10
C07D 401/12
C07D 403/10
C07D 409/14
C07D 417/14
A61P 27/02
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: MATTEI, Patrizio
HERT, Jérôme
HUNZIKER, Daniel
RUDOLPH, Markus
SCHMITZ, Petra
DI GIORGIO, Patrick
GOMME, Justin
Title: HETEROCYCLIC COMPOUNDS USEFUL AS DUAL ATX/CA INHIBITORS
Abstract:
The invention provides novel compounds having the general formula (I) wherein R1 is selected from substituted phenyl, pyridinyl or thiophenyl, R2 is selected from optionally substituted aminosulphonylphenyl, aminosulphonylpyridinyl, aminosulphonylthiophenyl or aminosulphonylthiazolyl, X is nitrogen or carbon, Y is a linking group, Z is a direct bond or a linking group, m = 0-5, n = 0-5 with the proviso that m+n is 2-5, compositions including the compounds and the use of the compounds in the treatment or prophylaxis of ocular conditions.