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1. WO2018166528 - PYRIMIDINYL-PYRIDYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF TREATING IRE1-RELATED DISEASES AND DISORDERS


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/CN2018/079292 F18W0498PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
16 March 2018 17 March 2017
Applicant
GENENTECH, INC. et al
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
This international search report has not been established in respect of certain claims under Article 17(2)(a) for the following reasons:
1.
Claims Nos.: 36-44
because they relate to subject matter not required to be searched by this Authority, namely:
[1] The subject matter of claims 36-44 relates to methods for treatment of human body by therapy. The SEARCH REPORT has been carried out and based on the subject matter of the use in the manufacture of medicaments for treating the corresponding diseases.
2.
Claims Nos.:
because they relate to parts of the international application that do not comply with the prescribed requirements to such an extent that no meaningful international search can be carried out, specifically:
3.
Claims Nos.:
because they are dependent claims and are not drafted in accordance with the second and third sentences of Rule 6.4(a).
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     C07D 403/04 (2006.01)i; C07D 403/14 (2006.01)i; A61K 31/4545 (2006.01)i; A61K 31/445 (2006.01)i; A61K 31/506 (2006.01)i; A61P 35/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     CO7D; A61K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
WPI,EPODOC,CNKI,CNPAT,STN,pyrimid+,pyrid+,naphthyl,pyridyloxy,kinase,cancer,tumour,tumor

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2005113494 A2 (AMGEN INC. ET AL.) 01 December 2005 (2005-12-01)
1-47
claims 1-42, examples 669, 670, 684, 687, 704, 705, 1050, 1078, 1079, 1109 and 1114
(2)
Y
WO 2007100646 A1 (AMGEN INC. ET AL.) 07 September 2007 (2007-09-07)
1-47
claims 1-26, examples 22, 35, 51, 52, 123
(3)
Y
Harrington, Paul E. et al., "Unfolded Protein Response in Cancer: IRE1α Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability", ACS Medicinal Chemistry Letters,Vol. 6, No. 1, 24 September 2014 (2014-09-24),
1-47
pages 68-72, compounds 5-19
(4)
Y
Cheng, Alan C. et al., "Analysis of Kinase Inhibitor Selectivity using a Thermodynamics-Based Partition Index", Journal of Medicinal Chemistry,Vol. 53, No. 11, 11 May 2010 (2010-05-11),
1-47
pages 4502-4510, compounds 1-2 and 11-12
(5)
Y
Cee, Victor J. et al., "Pyridyl-pyrimidine benzimidazole derivatives as potent, selective, and orally bioavailable inhibitors of Tie-2 kinase", Bioorganic & Medicinal Chemistry Letters,Vol. 19, No. 2, 20 November 2008 (2008-11-20),
1-47
pages 424-427, compound 9
(6)
Y
WO 2005113494 A2 (AMGEN INC. ET AL.) 01 December 2005 (2005-12-01)
1-47
claims 1-42, examples 669, 670, 684, 687, 704, 705, 1050, 1078, 1079, 1109 and 1114
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2005113494 A2
01 December 2005
WO 2005113494 A3
AU 2005245386 A1
EP 1751136 A2
ES 2505090 T3
JP 2007536280 A
US 2011201602 A1
US 2006009453 A1
US 7880000 B2
AU 2005245386 B2
CA 2564355 C
MX PA06012613 A
US 8476434 B2
EP 1751136 B1
JP 5097539 B2
CA 2564355 A1
16 March 2006
01 December 2005
14 February 2007
09 October 2014
13 December 2007
18 August 2011
12 January 2006
01 February 2011
27 November 2008
03 July 2012
31 January 2007
02 July 2013
02 July 2014
12 December 2012
01 December 2005
WO 2007100646 A1
07 September 2007
CA 2643177 A1
ES 2347489 T3
DE 602007008694 D1
EP 1994030 A1
US 7868177 B2
US 2007213325 A1
AT 478861 T
AU 2007221294 A1
CA 2643177 C
EP 1994030 B1
AU 2007221294 B2
07 September 2007
29 October 2010
07 October 2010
26 November 2008
11 January 2011
13 September 2007
15 September 2010
07 September 2007
14 June 2011
25 August 2010
25 August 2011
Name and mailing address of the ISA/:
STATE INTELLECTUAL PROPERTY OFFICE OF THE P.R.CHINA
6, Xitucheng Rd., Jimen Bridge, Haidian District, Beijing 100088
China
Facsimile No. (86-10)62019451
Date of the actual completion of the international search:
25 April 2018
Date of mailing of the international search report:
07 June 2018
Authorized officer:
DAI,Nianzhen
Telephone No. 86-(10)-53962137
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