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1. (WO2018166505) ACETOPHENONE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN FATTY LIVER PREVENTION AND TREATMENT
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Pub. No.: WO/2018/166505 International Application No.: PCT/CN2018/079181
Publication Date: 20.09.2018 International Filing Date: 15.03.2018
IPC:
C07D 213/82 (2006.01) ,C07C 235/24 (2006.01) ,C07C 235/20 (2006.01) ,C07C 231/02 (2006.01) ,C07C 235/26 (2006.01) ,C07C 251/16 (2006.01) ,A61K 31/222 (2006.01) ,A61K 31/166 (2006.01) ,C07C 235/84 (2006.01) ,A61P 3/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78
Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
81
Amides; Imides
82
in position 3
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02
having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04
the carbon skeleton being acyclic and saturated
18
having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
24
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02
having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04
the carbon skeleton being acyclic and saturated
18
having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
20
having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
231
Preparation of carboxylic acid amides
02
from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02
having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
26
the carbon skeleton being saturated and containing rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
251
Compounds containing nitrogen atoms doubly- bound to a carbon skeleton
02
containing imino groups
04
having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
10
to carbon atoms of an unsaturated carbon skeleton
16
containing six-membered aromatic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
22
of acyclic acids, e.g. pravastatin
222
with compounds having aromatic groups, e.g. dipivefrine, ibopamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
16
Amides, e.g. hydroxamic acids
165
having aromatic rings, e.g. colchicine, atenolol, progabide
166
having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
70
having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
84
with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
Applicants:
上海柏翱纳吉医药科技有限公司 SHANGHAI BIOENERGY MEDICINE SCIENCE & TECHNOLOGY CO., LTD. [CN/CN]; 中国上海市 浦东新区蔡伦路780号4楼4-G室 Room 4-G, 4th Floor, No. 780, Cailun Road, Pudong New District Shanghai 201203, CN
Inventors:
董玉琼 DONG, Yuqiong; CN
刘全海 LIU, Quanhai; CN
沈俞 SHEN, Yu; CN
蔡文韬 CAI, Wentao; CN
Agent:
广州嘉权专利商标事务所有限公司 JIAQUAN IP LAW FIRM; 中国广东省广州市 天河区黄埔大道西100号富力盈泰广场A栋910张萍 ZHANG, Ping No.910, Building A, Winner Plaza, No.100, West Huangpu Avenue, Tianhe District Guangzhou, Guangdong 510627, CN
Priority Data:
201710161146.817.03.2017CN
Title (EN) ACETOPHENONE COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN FATTY LIVER PREVENTION AND TREATMENT
(FR) COMPOSÉ ACÉTOPHÉNONE, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION DANS LA PRÉVENTION ET LE TRAITEMENT DU FOIE GRAS
(ZH) 苯乙酮类化合物、其制备方法及在防治脂肪肝方面的应用
Abstract:
(EN) Disclosed are a compound represented by formula I or a pharmaceutically acceptable salt thereof, a preparation method therefor, and an application thereof in preventing or treating fatty liver or in preparing weight-reducing drugs.
(FR) L'invention concerne un composé représenté par la formule I ou un sel pharmaceutiquement acceptable de celui-ci, un procédé de préparation associé, et une application de celui-ci dans la prévention ou le traitement du foie gras ou dans la préparation de médicaments réduisant le poids.
(ZH) 本发明公开了如式I所示化合物或其药学上可接受的盐及其制备方法,以及其在在制备预防或治疗脂肪肝或减肥的药物中的应用。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)