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1. (WO2018166307) SPECIFIC CHIMERIC ANTIGEN RECEPTOR T-CELL TARGETING NKG2DL, PREPARATION METHOD AND USE THEREOF

Pub. No.:    WO/2018/166307    International Application No.:    PCT/CN2018/075389
Publication Date: Fri Sep 21 01:59:59 CEST 2018 International Filing Date: Wed Feb 07 00:59:59 CET 2018
IPC: C07K 16/28
C12N 5/10
C12N 15/62
C12N 15/86
A61K 39/00
A61P 35/00
Applicants: NANJING KAEDI BIOTECH INC
南京凯地生物科技有限公司
Inventors: DAI, Hongjiu
代红久
SUN, Bin
孙彬
ZHAO, Xudong
赵旭东
Title: SPECIFIC CHIMERIC ANTIGEN RECEPTOR T-CELL TARGETING NKG2DL, PREPARATION METHOD AND USE THEREOF
Abstract:
Disclosed are a specific chimeric antigen receptor targeting NKG2DL, a coding sequence thereof, and immune response cells modified by same, and the preparation method and use thereof. The modified immune response cells can effectively target and attack multiple tumour cells, in particular, positive tumour cells expressing NKG2DL, and can be used to prepare a preparation for treating tumours.