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1. (WO2018165913) SPECIFIC CHIMERIC ANTIGEN RECEPTOR TARGETING NKG2DL AND CAR-T CELL THEREOF AND USE THEREOF
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Pub. No.: WO/2018/165913 International Application No.: PCT/CN2017/076795
Publication Date: 20.09.2018 International Filing Date: 15.03.2017
IPC:
C07K 19/00 (2006.01) ,C12N 15/62 (2006.01) ,C12N 15/63 (2006.01) ,C12N 5/10 (2006.01) ,C12N 15/861 (2006.01) ,C12N 15/867 (2006.01) ,A61K 35/17 (2015.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
861
Adenoviral vectors
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
867
Retroviral vectors
[IPC code unknown for A61K 35/17]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
南京凯地生物科技有限公司 NANJING KAEDI BIOTECH INC [CN/CN]; 中国江苏省南京市 江宁区诚信大道885号诚信大厦718室 Room 718, Chengxin Building 885 Chengxin Ave, Jiangning District Nanjing, Jiangsu 211102, CN
Inventors:
代红久 DAI, Hongjiu; CN
张征 ZHANG, Zheng; CN
李晓亮 LI, Xiaoliang; CN
周杰 ZHOU, Jie; CN
赵旭东 ZHAO, Xudong; CN
熊波 XIONG, Bo; CN
Agent:
苏州中合知识产权代理事务所(普通合伙) SUZHOU ZHONGHE INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP); 中国江苏省苏州市 工业园区新平街388号腾飞创新园A2楼416 Room 416, A2 Building, Ascendas iHub No.388 Xinping Street, Industrial Park Suzhou, Jiangsu 215021, CN
Priority Data:
Title (EN) SPECIFIC CHIMERIC ANTIGEN RECEPTOR TARGETING NKG2DL AND CAR-T CELL THEREOF AND USE THEREOF
(FR) RÉCEPTEUR ANTIGÉNIQUE CHIMÉRIQUE SPÉCIFIQUE CIBLANT NKG2DL, CELLULE CAR-T DE CELUI-CI ET SON UTILISATION
(ZH) 靶向NKG2DL的特异性嵌合抗原受体及其CAR-T细胞以及它们的应用
Abstract:
(EN) Provided are a specific chimeric antigen receptor targeting NKG2DL and a CAR-T cell thereof, as well as a preparation method and the use thereof. The CAR-T cell can effectively target and attack a plurality of tumour cells, and can be used to prepare a preparation for treating tumours, in particular, a preparation for treating positive tumour cells expressing NKG2DL.
(FR) L'invention concerne un récepteur antigénique chimérique spécifique ciblant NKG2DL et une cellule CAR-T de celui-ci, ainsi qu'un procédé de préparation et l'utilisation de celui-ci. La cellule CAR-T peut efficacement cibler et attaquer plusieurs cellules tumorales, et peut être utilisée pour préparer une préparation afin de traiter des tumeurs, en particulier, une préparation pour traiter des cellules tumorales positives exprimant NKG2DL.
(ZH) 提供了一种靶向NKG2DL的特异性嵌合抗原受体及其CAR-T细胞,以及它们制备方法和应用。该CAR-T细胞能有效地靶向攻击多种肿瘤细胞,可用来制备用于治疗肿瘤的制剂,尤其是表达NKG2DL阳性肿瘤细胞的制剂。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)